Supplemental Table 1: Contrast media used and unit costs across countries, € 2013

Cost item / Use of contrast media / Austria / Germany / Italy / Korea / Spain / Sweden / Switzerland / Thailand
Contrast media
Gd-EOB-DTPA-MRI / Primovist (gadoxetic acid disodium) 0.25 mmol/ml 10ml x 1 / 158.521 / 238.835 / 367.149 / 101.9718 / 235.5613 / 185.5120 / 257.8124 / 189.3426
ECCM-MRI
Magnevist (gadopentatedimeglumine) 0.5 mmol/ml, 10ml x 1 / 32.74% / 108.871 / 71.015 / 58.869 / 20.2418 / 52.3413 / 53.1120 / 83.8724 / 16.9626
Dotarem (gadoteric acid or gadoterate) 0.5 mmol/ml, 10ml x 1 / 10.62% / 91.051 / 80.465 / 52.079 / 32.7118 / 19.5613 / 41.6820 / 83.9924 / 47.7626
Gadovist (gadobutrol) 1.0 mmol/ml, 10ml x 1 / 55.75% / 135.891 / 134.655 / 129.809 / 54.6018 / 115.7413 / 101.9320 / 150.3024 / 109.6526
Omniscan (gadodiamide) 0.5 mmol/ml, 10ml x 1 / 0.88% / 76.011 / n/a / 42.429 / 21.9418 / 23.3813 / 33.8720 / 74.7624 / n/a
CE-CT / Iomeron* (iomeprol) 300 mg/ml, 1ml x 1 / 9.82% / 0.831 / n/a / 0.879 / 0.3918 / 0.5913 / 0.4420 / 0.8024 / 0.3926
Iomeron (iomeprol) 350 mg/ml, 1ml x 1 / 0.89% / 0.991 / n/a / 1.779 / 0.4418 / 1.1913 / 0.5320 / 0.8724 / n/a
Iomeron (iomeprol) 400 mg/ml, 1ml x 1 / 8.93% / 1.031 / n/a / 1.659 / 0.4818 / 1.5613 / 0.6120 / 0.9824 / 0.3726
Iopamiro* 370 mg/ml, 1ml x 1 / 3.57% / n/a / n/a / 0.709 / 0.3518 / 0.8813 / n/a / 0.8124 / 0.2926
Omnipaque* (iohexol) 350 mg/ml, 1ml x 1 / 2.68% / 0.821 / 0.925 / 0.459 / 0.4318 / 0.5013 / 0.2620 / 0.7124 / 0.2826
Opitray 320 mg/ml, 1ml x 1 / 0.89% / 0.871 / n/a / n/a / 0.4118 / 0.5213 / 0.3120 / 0.8024 / 0.2526
Radisense 300mg/ml, 1ml x 1 / 0,89% / n/a / n/a / n/a / 0.3218 / n/a / n/a / n/a / n/a
Ultravist* (iopromide) 370 mg/ml, 1ml x 1 / 13,39% / 0.541 / 0.935 / 0.759 / 0.3918 / 0.5213 / 0.5520 / 0.9924 / 0.2326
Xenetix* 350 mg/ml, 1ml x 1 / 1,78% / 0.881 / 0.975 / 0.999 / 0.3618 / 0.9513 / 0.5420 / 0.9524 / 0.3226
Imaging procedures, without contrast agent
Magnetic Resonance Imaging (MRI) / 148.634 / 185.387 / 192.588 / 191.8918 / 363.4014 / 358.5821 / 303.2925 / 211.2928
3-phase Computed Tomography (CT) / 298.934 / 109.557 / 106.408 / 95.7018 / 106.7914 / 191.2421 / 243.5425 / 178.2228
Costs for liver surgery
Cost per minute under anesthesia / 6.262 / 6.262 / 52.7810 / 5.0119 / 51.1815 / 18.7322 / 20.9225 / 49.9027
Cost per day in standard hospital care / 644.783 / 238.427 / 370.6711 / 198.1819 / 348.6616 / 482.7822 / 675.4025 / 10.6927
Cost per day in intensive care unit / 2385.483 / 1302.966 / 963.3412 / n/a / 741.6017 / 2880.8923 / 1925.6225 / 24.9627

*For the following imaging’s, no concentration was specified: Iomeron:14.29%; Iopamiro:10.71%; Omnipaque:1.79%; Ultravist:23.21%; Xenetix:7.14%.

1: Austria Codex: or

2: Stoffels et al. Reliability and cost-effectiveness of sentinel lymph node excision under local anaesthesia versus general anaesthesia for malignant melanoma: a retrospective analysis in 300 patients with malignant melanoma AJCC Stages I and II. J EurAcadDermatolVenereol. 2011;25(3):306-10

3: BundesministeriumfürGesundheit: STATIONÄRE KOSTEN in landesgesundheitsfondsfinanziertenKrankenanstalten 2001-2010,

4:AKH Wien, Ambulanz-selbstzahler-katalog 2012,

5:Rote Liste® Service GmbH, FachInfo-Service, Fachinformationsverzeichnis Deutschland, 2012,

6: Martin et al. Cost of intensive care in a German hospital: cost-unit accounting based on the InEK matrix. Anaesthesist. 2008;57(5):505-12.

7: MarienKrankenhaus “DRG-Entgelttarif” (Diagnosis Related Groups – scale of fees and charges) for hospitals as valid within the KHEntgG and patient information according to § 8 KHEntgG

8: TariffeambulatorialiLombardia (10.01.2010)

9:

10: “Iltariffariodi minima delleprestazioniliberoprofessionali in Anestesia e Rianimazione Anno 2011” and “Tariffariounicoaziendale 2011 (aziendaospedaliera Bologna)”

11: Fattore G & Torbica A. "Inpatient reimbursement system in Italy: How do tariffs relate to costs?" Health Case Manage Sci (2006) 9:251-258; Tariffaunicaconvenzionale per le prestazionidiassistenzaospedalieraregole e tariffevalide per l'anno 2009

12: Assuming the ratio ICU/overnight as in the UK: NHS Trusts Critical Care Services - Adult: Critical Care Unit (TCCSALCCU) Average of Code: XC01Z-XC07Z, NSRC1-NHS trust reference cost schedules 2010-2011.

13:

14: Mayordomo JI et al. Retrospective cost analysis of management of febrile neutropenia in cancer patients in Spain. Curr Med Res Opin. 2009;25(10):2533-42.

15: Since it was not possible to find sources for “Cost per anaesthesia minute in the operating theatre”. To obtain a cost: the DRG cost for liver resection was divided by the average time of liver resection surgery. Average duration of liver resection was calculated to be 282,5 minutes based on these source s: a) Otmane N et al. Hepatic Resection-Related Hypophosphatemia Is of Renal Origin as Manifested by Isolated Hyperphosphaturia. Ann Surg. 2007; 245(6): 1000–1002 (reports mean operative duration for liver resection of 205 ± 15 minutes), b) Taschieri AM et al. Repeated liver resection for recurrent metastases from colorectal cancer. Taschieri AM, Elli M, Vignati GA, Montecamozzo G, Danelli PG, Kurihara H, Poliziani D. Hepatogastroenterology. 2003;50(50):472-4. (reports mean operative duration for liver resection of 320 minutes) c) Jovine E et al. Major hepatectomy in patients with synchronous colorectal liver metastases: whether or not a contraindication to simultaneous colorectal and liver resection? (reports mean operative duration for liver resection of 322.5 +/- 59.5 min).

16:

17: Burchardi et al. Economic Aspects of Severe Sepsis A Review of Intensive Care Unit Costs, Cost of Illness and Cost Effectiveness of Therapy. Pharmacoeconomics 2004; 22 (12): 793-813

18: Price list from Korea Health Insurance Review Agency, as of July 25, 2012,

19: Lee et al. The epidemiology and cost of surgical site infections in Korea: a systematic review. J Korean Surg Soc. 2011 Nov;81(5):295-307

20: (accessed on 26-Jun-2012)

21: RegionalapriserochersättningarförSödrasjukvårdsregionen 2011

22: Price List SRVN Malmö/Lund, 2007, Lund: SödraRegionvårdsnämnden. And converted to 2011 with CPI health in Sweden

23: Price List Linköping University Hospital, 2007, Linköping: SydöstraSjukvårdsregionen. And converted to 2011 with CPI health in Sweden

24: Ferderal Office of Public Health Current SL data base (

25: TARMED Suisse (

26: Drug Price index, MoPH Apr-Jun 2011 (Updated on Feb 2012),

27: Standard cost list for HTA, HITAP (CPI 2007),

28: Reimbursement in government hospital 2006,

29: Red Book 2012

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