UCSF Lab Standard Operating Procedure

UCSF Lab Standard Operating Procedure

Chemical Process, Name or Hazard Class:

Acrylonitrile

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Type of SOP: ☐ Process ☒Hazardous Chemical ☐ Hazardous Class

Purpose

Acrylonitrile (also called vinyl cyanide) is a highly flammable chemical. It is toxic if inhaled, ingested or absorbed through skin. It can undergo explosive polymerization when exposed to heat, light, strong acid, or strong bases. It is used in the synthesis of various plastics such as high impact acrylonitrile-butadiene-styrene (ABS) plastics found in business machines, luggage, and construction material. It can also be used to make styrene-acrylonitrile (SAN) plastics used in automotive and household goods. Dimerization of monomeric acrylonitrile forms adiponitrile, a chemical used to make nylon, dyes, drugs, and pesticides.

Physical & Chemical Properties/Definition of Chemical Group

CAS#: 107-13-1

Class: Highly flammable, toxic, potentially explosive, carcinogen

Molecular Formula: C3H3N

Form (physical state): Liquid

Color: Colorless

Boiling point: 77 °C

Potential Hazards/Toxicity

Acylonitrile is a highly flammable liquid and vapor that should be kept away from heat, sparks, open flames, and hot surfaces. It can form explosive mixtures with air. It easily forms violently explosive polymerides when exposed to heat, light, strong bases, strong acids, and strong oxidizers. Components of the hazardous decomposition of acrylonitrile exposed to fire include carbon oxides, nitrogen oxides, and hydrogen cyanide.

Chemical is toxic if inhaled. Material is extremely destructive to the tissue of the mucous membranes and upper respiratory tract. It may cause allergy or asthma symptoms, breathing difficulties, or respiratory irritation if inhaled. It may be fatal if absorbed through skin. Causes skin burns. Causes eye burns. Toxic if swallowed. A potential carcinogen.

Engineering Controls

Chemical fume hood. Good ventilation. Electrically grounded lines and equipment.

Personal Protective Equipment (PPE)

Respirator Protection

If lab personnel would like to use respirator on a voluntary basis, they must be trained and fit-tested by EH&S. This is a regulatory requirement. (http://or.ucsf.edu/ehs/8193-DSY/version/default/part/4/data/)

Hand Protection

Handle with gloves (butyl gloves are recommended). Wash hands after use.

NOTE: Consult with your preferred glove manufacturer to ensure that the gloves you plan on using are compatible with acrylonitrile.

Refer to glove selection chart from the links below:

http://www.ansellpro.com/download/Ansell_8thEditionChemicalResistanceGuide.pdf

OR

http://www.allsafetyproducts.biz/page/74172

OR

http://www.showabestglove.com/site/default.aspx

OR

http://www.mapaglove.com/

Eye Protection

ANSI approved, tight-fitting safety glasses/goggles. Face shields are also recommended .

Skin and Body Protection

Flame resistant/cotton lab coat preferably made of antistatic material, long pants, and closed-toe shoes.

Hygiene Measures

Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

First Aid Procedures

If inhaled

Move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Take off contaminated clothing and shoes immediately. Wash skin with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact

Check for and remove any contact lenses. Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. Continue rinsing eyes during transport to hospital.

If swallowed

Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Special Handling and Storage Requirements

Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Use explosion-proof equipment. Keep away from sources of ignition - No smoking. Take measures to prevent the build-up of electrostatic charge.

Conditions for safe storage: Keep container tightly closed in a cool, dry, and well-ventilated place. Isolate from incompatible materials and conditions. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Light sensitive. Store in original container. Store away from heat sources and in a flame proof area.

Spill and Accident Procedure

Chemical Spill Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206-8522 (SFGH only)

Spill – Assess the extent of danger. Assist contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.).

Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic bags, label and take to the next chemical waste pick-up.

Large (>1 L) – Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206-8522 (SFGH only) for assistance.

Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working hours and weekends.

Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water for 15 minutes by forcibly holding the eye open. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working hours and weekends.

Medical Emergency Dial 9-911 (campus phone) or 476-6911 (cell phone)

Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.

Non-Life Threatening Emergency– Go to Occupational Health Programs (OHP) Clinic, 415-885-7580, 2330 Post Street, Suite 460 Hours of Operation for Appointments: Monday - Friday 7:30 a.m. - 4:00 p.m. (except Holidays).

Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.

Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick nurse by dialing 415-353-7842 (STIC).

Decontamination/Waste Disposal Procedure

Clean contaminated surfaces with soap and water and paper towels. Dispose of the paper towels as hazardous waste.

Safety Data Sheet (SDS) Location

Online SDS can be accessed at http://or.ucsf.edu/ehs/7241-DSY/msds.html

Protocol/Procedure

Quantities covered by this SOP:

______(g , ml) to ______(g, ml)

Temperature range covered by this SOP:

__ °C – __ °C

General Overview and Purpose:

Enter the experimental purpose

Procedure:

Enter experimental procedure. You can copy procedure from your lab notebook or from literature.

NOTE

Any deviation from this SOP requires approval from the Principal Investigator.

Acrylonitrile 5 Date: Click here to enter a date.

Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)