Supplemental Material for the JI Website
Table 1. Global changes in human PMN gene expression
Gene Category: Metabolism & Vesicle Transport /GeneBank
/ Gene (Up-regulated) / FcR-phago. / CR-phago. / FcR/CR-phago. / anti-Fas mAb / Camptothecin / Time (min)Y08200 / RABGGTA: geranylgeranyl-transferase / 2.2, 2.8 / 2.0, 2.7 / 2.2, 2.0 / -1.1, -1.3 / 2.0, 1.2 / 180, 360
L20859 / SLC20A1: phosphate transporter / 3.6, 1.8 / 3.6, 1.7 / 3.6, 2.3 / -1.1, -2.4 / -2.0, -2.5 / 90, 360
J04988 / HSPCB: Hsp90, beta / 1.4, 2.8, 2.9 / 1.5, 1.9, 1.8 / 1.6, 1.8, 2.7 / ND, 1.1, 1.4 / ND, 1.1, 1.3 / 10, 90, 360
Y00371 / HSPA4: Hsp70 / 2.1 / 1.8 / 1.5 / 1.1 / 2.5 / 90
D13748 / EIF4A1: translation initiation factor / 2.1 / 1.9 / 2.4 / -1.7 / 1.6 / 360
M86752 / STIP1: Hsp70/Hsp90-organizing protein / 2.7 / 1.9 / 2.0 / -3.6 / 1.3 / 360
M16653 / ELA2B: pancreatic elastase IIB / 2.9 / 1.3 / 3.0 / 1.9 / 1.7 / 360
X72631 / NR1D1: hRev / 32.2, 16.6 / 31.6, 12.4 / 31.1, 16.6 / 2.2, 2.2 / 1.3, 2.6 / 180, 360
M90656 / GCLC: glutamate-cysteine ligase / 4.1, 8.1 / 2.9, 5.5 / 4.3, 7.6 / 1.4, 2.0 / 1.1, 1.9 / 180, 360
U52112 / ARD1: N-acetyltransferase / 1.8 / 2.2 / 2.0 / NC / 1.2 / 180
AF044253 / KCNAB2: K+ voltage-gated channel / 1.8, 2.2 / 2.1, 2.3 / 1.8, 2.8 / NC, -1.2 / -1.2, -2.1 / 180, 360
U67733 / PDE2A: phosphodiesterase 2A / NC, 2.0 / 2.6, 2.0 / 1.6, 1.1 / ND, -1.1 / ND, -1.3 / 30, 90
Y09568 / SNAP23: synaptosome-associated protein / NC / 2.4 / 2.4 / -1.1 / 3.8 / 90
X56253 / M6PR: M-6-P receptor / 2.4, 2.6 / 2.3, 2.6 / 2.2, 3.4 / NC, 1.2 / 1.2, NC / 180, 360
J05032 / DARS: aspartyl-tRNA synthetase / 2.0 / 2.1 / 2.0 / -1.3 / -4.9 / 360
L07956 / GBE1: glucan branching enzyme / 3.0 / 2.9 / 3.4 / -1.1 / -1.9 / 360
U05861 / AKR1C2: aldo-keto reductase / 2.4 / 1.4 / 2.3 / 2.1 / 1.3 / 360
W28734 / VPS11: vacuolar protein sorting 11 / 2.0, 2.6 / NC, 2.1 / NC, 2.6 / 1.1, NC / 2.0, 1.1 / 90, 360
M30474 / GGT2: gamma-glutamyltransferase / 2.4, 3.0 / 2.4, 2.5 / 2.7, 2.7 / -1.4, -3.6 / 1.4, NC / 180, 360
AL022165 / CHST7: carbohydrate sulfotransferase / 2.7, 2.6 / 1.8, 2.2 / 2.3, 2.3 / -1.2, NC / -1.8, -2.1 / 180, 360
AB011083 / ADCY3: adenylate cyclase 3 / 2.7 / 2.2 / 2.5 / 2.0 / 2.2 / 360
L35546 / GCLM: glutamate-cysteine ligase / 5.3 / 2.5 / 5.2 / 1.2 / NC / 360
U28424 / DNAJC3: DnaJ (Hsp40) homolog / 4.2 / 3.3 / 3.1 / -1.1 / -1.7 / 360
U12472 / GSTP1: glutathione S-transferase / 1.3 / 6.2 / 2.0 / 1.6 / 1.1 / 180
AI741756 / ATP6V1H: ATPase / 3.8, 2.7 / 3.2, 2.3 / 4.1, 1.9 / -1.3, -1.7 / -7.1, -5.2 / 180, 360
Z82244 / HMOX1: heme oxygenase / 3.3, 2.5, 2.2 / 2.2, 2.4, 2.2 / 6.4, 2.5, 2.9 / -1.7, -2.3, -5.5 / 1.3, -8.9, -5.5 / 90, 180, 360
AA877795 / ATP6V1D: ATPase / NC, 4.0, 3.5 / 2.1, 3.7, 3.3 / 2.7, 4.9, 3.5 / -1.1, -1.3, -2.5 / -1.2, -1.4, -3.7 / 90, 180, 360
AL080061 / CLIC4: chloride intracellular channel / 2.7 / 1.7 / 1.6 / -1.8 / -4.0 / 360
X71973 / GPX4: glutathione peroxidase / 1.9 / 1.8 / 1.9 / -1.2 / 1.1 / 360
U47924 / TPI1: triosephosphate isomerase / 3.1 / NC / NC / 1.1 / 1.7 / 90
AB026891 / SLC7A11: amino acid transporter / NC, 4.3 / -1.7, 3.7 / -2.7, 4.6 / ND, 2.6 / ND, 1.6 / 30, 360
X83378 / CLCN6: chloride channel 6 / 4.6, 2.9 / 4.8, 2.5 / 5.3, 2.8 / NC, 2.2 / 1.1, -1.5 / 180, 360
AB018356 / SIAT9: sialyltransferase 9 / 19.7 / 25.0 / 37.6 / 2.9 / 1.8 / 360
D31766 / GNPI: glucosamine-6-P isomerase / 44.1, 4.4, 4.1 / 35.4, 4.7, 4.2 / 45.5, 5.1, 4.9 / NC, 1.1, -2.0 / -1.2, -1.5, -2.6 / 90, 180, 360
AL096713 / FER1L3: myoferlin / 3.6 / 3.1 / 3.4 / 2.9 / 1.1 / 360
S70154 / ACAT2: thiolase / 5.6 / 3.7 / 4.7 / -1.6 / NC / 360
M23294 / HEXB: hexosaminidase / 1.9, 2.6 / 2.1, 2.5 / 3.1, 3.1 / NC, 3.0 / -1.9, NC / 180, 360
X15722 / GSR: glutathione reductase / 5.7 / 3.3 / 7.3 / -1.9 / -6.1 / 360
AF049891 / TPST2: tyrosylprotein sulfotransferase / 1.9 / 1.6 / 2.6 / NC / -1.1 / 360
AJ011679 / GAPCENA: GTPase activating protein / 1.9 / 1.8 / 2.1 / -2.1 / -10.3 / 360
AB004857 / SLC11A2: Nramp1 / 6.9 / 5.2 / 4.5 / 1.8 / 1.8 / 360
J04178 / HEXA: abnormal hexosaminidase / 12.4 / 11.5 / 13.6 / 1.3 / -2.7 / 180
U30894 / SGSH: sulfamidase / 2.1, 2.7, 3.3 / NC, 3.0, 3.3 / 1.4, 2.7, 4.1 / NC, NC, -1.4 / -1.2, -1.6, -1.3 / 90, 180, 360
D89618 / KPNA3: importin alpha / 2.5 / NC / 3.9 / ND / ND / 10
U67963 / MGLL: monoglyceride lipase / 4.7, 11.9 / 2.2, 10.6 / 5.1, 14.2 / 2.0, 1.5 / -1.1, NC / 180, 360
AL080081 / DNAJB9: DnaJ (Hsp40) homolog / 2.6 / 2.0 / 3.1 / -1.5 / 2.6 / 180
AF002210 / CCS: copper chaperone for SOD / 11.0 / 17.7 / 8.9 / ND / ND / 30
M63959 / LRPAP1: LDL-related protein-assoc. protein / 1.7 / 2.0 / 2.2 / -1.6 / NC / 360
Z12173 / GNS: glucosamine-6-sulfatase / 1.5, 2.6 / 2.4, 2.3 / 1.8, 1.9 / 1.7, 1.1 / 1.6, -4.2 / 90, 360
AL049538 / RIN2: Rab5 interacting protein / 3.3, 2.0 / 2.7, 1.8 / 3.0, 1.7 / 1.7, 2.5 / 1.1, 1.4 / 180, 360
AJ222967 / CTNS: cystinosin / NC, 3.3, 2.4 / 1.9, 3.6, 2.2 / 2.4, 4.5, 2.7 / 1.2, 1.3, -1.1 / 1.2, 1.5, -2.3 / 90, 180, 360
U09510 / GARS: glycyl-tRNA synthetase / 2.2, 2.7, 3.1 / 1.8, 2.6, 2.7 / 2.0, 3.2, 2.9 / 1.1, 1.3, -1.3 / -1.6, -1.2, 1.2 / 90, 180, 360
X15414 / AKR1B1: aldose reductase / 1.5, 2.9 / 2.0, 1.8 / 9.2, 1.9 / 1.1 / -1.3 / 30, 90
X87176 / HSD17B4: hydroxysteroid dehydrogenase / 12.3, 16.6 / 10.9, 15.5 / 12.4, 17.9 / -2.2, -2.8 / -1.6, -4.4 / 180, 360
L01664 / CLC: lysophospholipase / 1.7 / 1.5 / 3.4 / -1.3 / -2.5 / 360
U78027 / GLA: galactosidase, alpha / 2.1, 2.2 / NC, 1.9 / 1.7, 2.1 / -1.1, -2.0 / -1.7, -2.3 / 90, 360
Z29331 / UBE2H: ubiquitin-conjugating enzyme / 5.4 / 2.6 / 2.1 / -2.9 / -7.5 / 360
U39412 / NAPA: NEM attachment protein / 2.2 / 1.8 / 2.1 / -1.6 / -1.4 / 360
AI653621 / TXN: thioredoxin / 2.3 / 2.0 / 2.6 / -1.1 / 1.3 / 360
D32143 / BLVRB: biliverdin reductase B / 1.9 / 1.9 / 2.3 / NC / 1.5 / 360
U24577 / PLA2G7: phospholipase A2 / 4.5, 3.5 / 4.0, 3.3 / 3.4, 3.6 / 1.4, 3.4 / -1.2, 2.2 / 180, 360
X91817 / TKTL1: transketolase / 2.1, 2.9 / 2.3, 2.8 / 2.6, 2.3 / -1.1, 1.5 / 1.1, 1.4 / 180, 360
L07765 / CES1: carboxylesterase / 5.3 / 1.8 / 4.5 / 15.6 / 2.9 / 360
AF010400 / TALDO1: transaldolase / 1.2 / 1.5 / 2.1 / -2.0 / -1.9 / 360
M20867 / GLUD1: glutamate dehydrogenase / NC / 2.1 / 1.8 / ND / ND / 30
D49400 / ATP6V1F: ATPase / 2.4, 2.9 / 2.2, 2.8 / 2.4, 3.3 / 1.5, 1.3 / 1.4, -1.4 / 180, 360
AF037066 / SLC22A1LS: organic cation transporter / 3.2, 4.8, 9.5 / 3.1, 3.8, 9.2 / 3.5, 4.7, 8.0 / 1.1, 1.5, 2.1 / -1.5, -1.1, 1.1 / 90, 180, 360
AB002303 / ENDOFIN: FYVE-domain protein / 1.9, 3.1, 3.4 / 2.4, 2.8, 2.8 / 2.5, 3.3, 3.2 / 1.2, -1.8, -1.9 / -1.7, -5.7, -4.4 / 90, 180, 360
J05682 / ATP6V1C1: ATPase / 3.1 / 2.9 / 3.0 / -1.5 / -1.7 / 360
J02939 / SLC3A2: amino acid transport / 2.5, 1.6 / 1.7, 1.7 / 2.3, 2.2 / NC, -2.3 / NC, -1.3 / 90, 360
Z67743 / CLCN7: chloride channel 7 / 3.1, 3.4 / 3.2, 3.4 / 3.1, 3.8 / 1.3, 1.7 / 1.1, 1.1 / 180, 360
AB007858 / RNMT: RNA methyltransferase / 2.0, 2.7 / 2.5, 2.5 / 2.6, 3.1 / 1.1, -1.6 / -4.4, -1.4 / 90, 180
D80010 / LPIN1: lipin / 2.0 / 2.1 / 2.3 / 2.0 / -1.2 / 360
X78711 / GK: glycerol kinase / NC / 2.2 / 1.7 / 1.3 / 1.4 / 90
AC002540 / SLC25A13: citrin / 6.8, 11.6 / 5.8, 10.6 / 6.8, 10.2 / -1.5, -1.3 / -1.7, -2.7 / 180, 360
U96721 / HPS: Hermansky-Pudlak syndrome / 2.0 / 1.8 / 2.2 / 2.1 / -1.1 / 360
AI679353 / SLC11A1: Nramp1 / 2.1, 1.5 / 1.4, 1.7 / 6.6, 3.0 / NC / -1.9 / 30, 90
Z69043 / SSR4: signal sequence receptor / 7.1 / 7.0 / 7.4 / NC / 1.7 / 90
M88279 / FKBP4: FK506-binding protein 4 / 2.2 / 3.1 / 2.3 / ND / ND / 30
J04794 / AKR1A1: aldehyde reductase / NC, 2.2 / 2.0, 2.1 / 1.7, 2.0 / 1.1, -1.7 / -1.2, -1.3 / 90, 360
AL008726 / PPGB: beta-galactosidase protective protein / 2.8, 4.7 / 2.7, 4.1 / 3.0, 5.0 / -1.2, -2.2 / 3.3, 1.3 / 180, 360
AF040958 / NEU1: sialidase 1 (lysosomal sialidase) / 5.3, 5.8, 5.1 / 4.8, 5.9, 4.7 / 7.8, 7.5, 5.1 / -1.3, -1.3, -5.3 / 1.8, 2.0, -2.1 / 90, 180, 360
U43286 / SPS2: selenophosphate synthetase 2 / 2.5, 2.1, 2.1 / 1.8, 1.5, 1.6 / 1.6, 2.0, 1.6 / NC, NC, 1.2 / 1.2, NC, -1.3 / 90, 180, 360
U22526 / LSS: lanosterol synthase / 2.5 / 1.5 / 1.6 / 1.8 / 2.0 / 360
AB022918 / ST3GALVI: alpha2,3-sialyltransferase / 2.1, 1.8 / 2.6, 1.7 / 3.1, 2.2 / 1.1, -1.8 / 1.6, -1.8 / 90, 180
M16424 / HEXA: hexosaminidase / 5.0, 9.4, 15.3 / 4.1, 7.9, 11.9 / 4.8, 9.9, 14.6 / 1.1, 1.4, -2.9 / 1.4, 1.4, -4.8 / 90, 180, 360
X91247 / TXNRD1: thioredoxin reductase 1 / 1.7 / 1.6 / 2.1 / -1.8 / -2.8 / 360
X74837 / MAN1A1: mannosidase, alpha / NC / 2.2 / 1.4 / -1.1 / 1.4 / 90
U14528 / SLC26A2: sulfate transporter / 1.5 / 1.3 / 1.3 / 1.2 / -4.2 / 90
M55621 / MGAT1: acetylglucosaminyltransferase / 2.1, 2.0 / 2.3, 2.8 / 2.1, 2.3 / 1.1, -1.1 / -1.1, 1.2 / 180, 360
M94856 / FABP5: fatty acid binding protein 5 / 1.7 / 2.2 / 3.5 / 1.4 / 2.7 / 360
AB004550 / B4GALT5: beta 1,4- galactosyltransferase / 2.7, 3.1 / 1.0, 2.4 / 1.9, 1.8 / -3.2, -1.1 / -1.2, -1.3 / 180, 360
U18009 / VATI: vesicle amine transport protein / 1.5, 2.4 / 1.9, 2.3 / 2.1, 2.6 / 1.3, 1.6 / 1.2, 1.3 / 180, 360
L13972 / SIAT4A: sialyltransferase 4A / 16.9 / 8.6 / 11.7 / 1.1 / 1.3 / 360
U66676 / ABCB9: ATP-binding cassette / NC / NC / 1.6 / NC / -1.1 / 90
X83573 / ARSE: arylsulfatase E / 2.6, 5.4 / 2.9, 4.7 / 4.8, 5.8 / 1.6, 1.6 / 1.3, 2.0 / 180, 360
AL080119 / PAI-RBP1: PAI-1 mRNA-binding protein / 1.7 / 2.1 / 2.2 / ND / ND / 10
AB018566 / PROSC: Pro synthetase co-transcribed / 1.7, 2.1 / 2.3, 1.2 / 1.7, 1.4 / 1.8, -1.8 / 1.3, 1.4 / 90, 180
U10868 / ALDH3B1: aldehyde dehydrogenase / 1.8 / 1.6 / 2.0 / -1.3 / 1.1 / 180
AA705628 / SLC16A5: monocarboxylic acid transporter / 2.1, 2.5, 2.7 / 1.6, 2.5, 2.3 / 2.1, 2.6, 2.4 / -1.1, -1.7, -1.9 / 1.3, -1.6, -4.3 / 90, 180, 360
U04953 / IARS: isoleucine-tRNA synthetase / 2.3, 2.5 / 1.9, 2.2 / 2.3, 2.1 / 1.7, 2.8 / 1.8, 1.4 / 180, 360
J04973 / UQCRC2: ubiquinol-cytochrome c reductase / 2.5, 4.8 / 2.3, 4.4 / 2.6, 5.0 / -1.8, -1.4 / -1.8, -1.4 / 180, 360
U36310 / GPD2: glycerol-3-P dehydrogenase / 2.8, 2.0 / 2.3, 2.0 / 3.5, 2.0 / 1.5, 3.3 / -1.6, 1.5 / 180, 360
M15856 / LPL: lipoprotein lipase / 2.9 / 2.7 / 3.0 / 2.4 / 2.1 / 360
X67951 / PRDX1: peroxiredoxin / 2.7 / 2.5 / 2.6 / -1.3 / -1.6 / 360
D84273 / NARS: asparaginyl-tRNA synthetase / 1.9, 2.8, 2.0 / 2.1, 2.8, 2.0 / 2.2, 3.1, 2.4 / NC, 1.1, -1.8 / 1.6, -1.8, -2.7 / 90, 180, 360
AJ007583 / LARGE: like-glycosyltransferase / 2.0 / NC / 1.5 / NC / -1.2 / 90
AF053003 / DPH2L2: diphthamide biosynthesis / 3.4 / 2.9 / 3.2 / 6.1 / 1.3 / 360
L11066 / HSPA9B: heat shock 70kD protein 9B / 2.1, 2.3, 2.7 / NC, 1.8, 2.3 / 1.8, 2.3, 1.9 / 1.3, -1.1, 1.6 / -1.4, 1.8, -2.7 / 90, 180, 360
U59878 / RAB32: Rab32 / 1.7, 2.2, 2.7 / 2.0, 3.2, 2.4 / 2.2, 3.9, 3.1 / NC, -1.3, -4.2 / 1.4, -1.3, -1.8 / 90, 180, 360
J04131 / GGT1: gamma-glutamyltransferase 1 / 2.0, 2.4 / 2.2, 2.1 / 2.2, 2.4 / 1.1, -1.9 / 1.3, 1.7 / 180, 360
U32680 / CLN3: ceroid-lipofuscinosis, neuronal 3 / 1.9 / 1.7 / 2.0 / 1.1 / -1.7 / 360
U77604 / MGST1: microsomal GST / 3.2 / 2.3 / 2.2 / 1.6 / 2.8 / 180
M13792 / ADA: adenosine deaminase / 4.0, 5.5 / 2.9, 5.1 / 3.2, 4.6 / 1.3, 4.5 / NC, 1.9 / 180, 360
AF002020 / NPC1: Niemann-Pick disease protein / 4.8, 5.2 / 3.5, 3.9 / 4.9, 4.7 / -1.3, 1.1 / -2.4, -1.6 / 180, 360
Down-regulated
X51757 / HSPA6: heat shock 70kD protein 6 / -1.8 / -2.0 / -2.9 / -2.7 / -1.2 / 360
L13852 / UBE1L: ubiquitin-activating enzyme / -2.3 / -2.2 / -2.4 / 1.1 / 1.3 / 360
U73379 / UBE2C: ubiquitin-conjugating enzyme / -4.9 / -1.4 / -5.7 / -1.2 / -1.6 / 90
U83661 / ABCC5: ATP-binding cassette / -2.6, -4.0 / -1.6, -3.7 / -2.1, -3.2 / 1.3, -1.3 / 2.1, 1.1 / 180, 360
M21154 / AMD1: S-adenosylmethionine decarboxylase / -2.0, -2.9 / -2.2, -2.5 / -2.1, -3.9 / -1.8, -2.6 / -2.7, -2.6 / 180, 360
L40387 / TRIP14: thyroid receptor interactor 14 / -1.6 / -1.6 / -2.2 / -1.1 / -2.3 / 360
J03600 / ALOX5: arachidonate 5-lipoxygenase / -1.7 / -1.7 / -2.3 / -1.5 / -1.1 / 360
U82277 / PGK: alternatively spliced PGK / -1.9 / -1.7 / -2.2 / 1.1 / -1.9 / 360
X07315 / NUTF2: nuclear transport factor 2 / NC / -3.6 / NC / ND / ND / 10
AF015926 / SLC9A3R1: Na+/H+ exchanger / -2.4 / -1.9 / -2.3 / -1.4 / -1.2 / 360
AF007872 / TOR1B: torsin B / -1.8 / -1.9 / -2.1 / 1.1 / 2.4 / 360
X05409 / ALDH2: aldehyde dehydrogenase / -2.1 / -2.0 / -2.0 / -1.1 / NC / 360
AI796048 / PGCP: plasma glutamate carboxypeptidase / -1.7 / -2.1 / -2.4 / -2.2 / -4.2 / 360
AJ002078 / STX6: syntaxin 6 / -2.1, -2.5 / -2.2, -2.0 / -4.0, -3.3 / -1.5, -1.1 / -2.6, -2.0 / 180, 360
U17566 / SLC19A1: folate transporter / -2.2 / -1.8 / -3.0 / -2.1 / -1.7 / 360
X66503 / ADSS: adenylosuccinate synthase / -1.4 / -1.5 / -2.0 / 1.5 / -1.7 / 180
U37221 / PPIL2: peptidylprolyl isomerase-like / -2.3 / -2.0 / -2.0 / 1.4 / 1.5 / 180
AB029020 / VDU1: deubiquitinating enzyme / -1.6, -1.8 / -1.8, -1.8 / -2.1, -2.2 / -1.7, -1.4 / -1.8, -5.6 / 180, 360
L41680 / SIAT8D: sialyltransferase 8 / -6.5, -2.4 / -5.0, -2.4 / -5.9, -2.7 / -1.7, 1.2 / -1.4, -5.5 / 180, 360
U39447 / AOC3: amine oxidase / -9.6 / -2.5 / -6.6 / 1.3 / NC / 360
X04327 / BPGM: 2, 3-bisphosphoglycerate mutase / -2.1, -3.4 / -2.0, -2.3 / -3.5, -3.1 / -1.2, -1.2 / -1.7, -1.8 / 180, 360
N25122 / p47: likely ortholog of rat p47 / -2.5, -2.6 / -3.0, -3.1 / -3.8, -8.3 / 1.1, 1.3 / 1.1, 1.2 / 180, 360
D89053 / FACL3: fatty-acid-Coenzyme A ligase / -2.6 / -1.8 / -2.2 / -1.1 / -1.2 / 360
U34252 / ALDH9A1: aldehyde dehydrogenase / -2.7, -2.6 / -2.2, -2.1 / -2.9, -2.9 / -1.3, -1.5 / -1.8, -3.4 / 180, 360
Y13834 / ZMPSTE24: zinc metalloproteinase / -2.1 / -2.2 / -2.3 / 1.1 / -3.6 / 360
AF038852 / CACNB4: calcium channel / -3.1 / NC / NC / 1.1 / -1.8 / 90
Y13350 / DNAJA2: DnaJ (Hsp40) homolog / -3.3, -2.8 / -2.4, -2.5 / -2.9, -3.1 / -1.1, -1.2 / -1.4, NC / 180, 360