CURRICULUM VITAE
BARRY H. GREENBERG, M.D.
NAME: Barry H. Greenberg, M.D.
PLACE OF BIRTH: Brooklyn, New York
MARITAL STATUS: Married to Jennifer Keithly Greenberg
HOME ADDRESS: 4853 Bayliss Court
San Diego, CA 92130
OFFICE ADDRESS: Sulpizio Cardiovascular Center
University of California, San Diego
9434 Medical Center Drive
La Jolla, CA 92093-7411
CORRESPONDENCE: Office: (858) 657-5267 (Administration)
(858) 657-8530 (Clinical)
FAX: (858) 657-5028
Home: (858) 794-7912
E-mail:
EDUCATION
1962 - 1966 Brooklyn College,
Brooklyn, New York; B.A., 1966
1966 - 1970 Upstate Medical Center
Syracuse, New York; M.D., 1970
1970 - 1971 Internship, Internal Medicine
George Washington University Hospital
Washington, DC
(Chairman: Wallace N. Jensen, M.D.)
1973 - 1975 Resident in Medicine
Yale-New Haven Hospital
New Haven, Connecticut
(Chairman: Samuel O. Thier, M.D.)
1975 - 1977 Postdoctoral Fellow in Cardiology
University of California
San Francisco, California
(Division Head: William W. Parmley, M.D.)
UNIVERSITY AND HOSPITAL STAFF APPOINTMENTS
1971 - 1973 Staff Associate, National Institute
Heart, Lung and Blood
Lipid Metabolism Branch
National Institutes of Health
Bethesda, Maryland
(Division Head: Robert I. Levy, M.D.)
1976 - 1977 Assistant Research Physician I
Cardiovascular Research Institute
San Francisco, California
1977 - 1992 Director, Coronary Care Unit
Oregon Health Sciences University
Portland, Oregon
1977 - 1981 Assistant Professor of Medicine
Division of Cardiology
Oregon Health Sciences University
Portland, Oregon
1981 - 1986 Associate Professor of Medicine with Tenure
Division of Cardiology
Oregon Health Sciences University
Portland, Oregon
1984 - 1985 Visiting Colleague
Respiratory Unit
Royal Postgraduate Medical School
Hammersmith Hospital
London, England
(Director: Prof. Peter Barnes)
1987 - 1995 Professor of Medicine
Division of Cardiology
Oregon Health Sciences University
Portland, Oregon
1988 - 1995 Collaborating Scientist
Oregon Regional Primate Research Center
Beaverton, Oregon
1991 - 1992 Visiting Professor
Laboratoire de Médicine Expérimentale
College de France
Paris, France
(Director: Prof. Pierre Corvol)
1995 - present Professor of Medicine
University of California, San Diego
San Diego, California
1995 - 2005 Director, Heart Failure/Cardiac Transplantation Program
2004 - present Faculty Member of the Sam and Rose Stein Institute for
Research on Aging
University of California, San Diego
San Diego, California
2005 - present Director, Advanced Heart Failure Treatment Program
University of California, San Diego
San Diego, California
MILITARY SERVICE
1971 - 1973 U.S. Public Health Service Assigned to the Lipid Metabolism Branch
of the National Institutes of Health
Bethesda, Maryland
HONORS AND AWARDS
1962 - 1966 Recipient of New York State Regents' Scholarship
1966 B.A., cum laude, Brooklyn College
1976 - 1977 Bay Area Heart Association Research Fellowship
1983 Elected to Western Society for Clinical Investigation
1987 Elected to Western Association of Physicians
1989 Elected to American Society of Pharmacology and Experimental
Therapeutics
1993 - Present Chosen each year for inclusion in “The Best Doctors in America“
2003 - 2007 Selected each year as one of the "The Best Doctors in San Diego"
2010 Recipient of the “Passionate Heart Award” from the American Heart
Association, San Diego Chapter
LICENSURE
Oregon Medical License 10875 (1977 – 1995)
California Medical License G029316 (1995 – present)
California Fluoroscopy License 144556
CERTIFICATION
1971 National Board of Medical Examiners
1975 American Board of Internal Medicine
1977 American Board of Internal Medicine - Cardiovascular Disease
2010 American Board of Internal Medicine – Advanced Heart Failure and
Transplant Cardiology
PROFESSIONAL SOCIETIES
American Heart Association, Fellow of the Councils of Circulation, Clinical Cardiology, and
Thrombosis
Fellow of the American College of Cardiology
Heart Failure Society of America (Founding Member)
International Society for Heart and Lung Transplantation
International Society for Heart Research, American Section
Western Association of Physicians
RESEARCH SUPPORT
1978 - 1979 Principal Investigator: American Heart Association, Oregon Affiliate Grant: "Long term vasodilator therapy for chronic congestive heart failure". $10,000
1980 - 1981 Principal Investigator: American Heart Association, Oregon Affiliate Research Grant: "Long term vasodilator therapy of mitral regurgitation". $16,700
1981 - 1982 Principal Investigator: Medical Research Foundation of Oregon: "Does long term vasodilator therapy improve left ventricular performance in aortic insufficiency?" $9,700
1982 - 1986 Principal Investigator: NHLBI 1‑R01‑HL28146 "Long term vasodilator therapy in aortic insufficiency." Funded for total of $541,300 over 4 years.
1983 - 1984 Principal Investigator: American Heart Association, Oregon Affiliate Grant: "Isometric exercise in heart failure: Effects of vasodilators". $18,250
1985 - 1986 Principal Investigator: NHLBI-R01-28146-04S1 "Long term vasodilator therapy of aortic insufficiency (competitive supplement for year 04)". $173,166
1985 - 1992 Principal Investigator: NHLBI 84-21 "Studies of left ventricular dysfunction (SOLVD) - Clinical centers". Funded for total of $1,263,836.
1985 - 1986 Principal Investigator: American Heart Association, Oregon Affiliate Research Grant: "Effects of peptide mediators on coronary vasomotor tone". $25,950
1985 - 1986 Principal Investigator: Dant Foundation of Oregon Research Grant: "Establishment of a Vascular Pharmacology Laboratory". $8,900
1988 - 1989 Principal Investigator: American Heart Association, Oregon Affiliate Research Grant "Fish Oil Effects on Atherosclerotic Arteries". $30,000
1990 - 1991 Principal Investigator: Medical Research Foundation of Oregon: "EDRF activity in the microvasculature of an experimental model of heart failure." $17,000
1991 - 1992 Principal Investigator: NIH Fogarty International Fellowship: "Expression of vasoactive genes in heart failure". $48,000
1994 - 1995 Preceptor for Dr. Jay Ambrose: Research Fellowship award from the Oregon Affiliate of the American Heart Association “Sarcoplasmic reticulum ATPase and phospholamban gene expression in an experimental model of myocardial infarction”. $21,000
1994 - 1996 Preceptor for Dr. Jay Ambrose: Individual National Research Service Award Application from NIH: “Relaxation abnormalities and Gene Expression after MI”. $48,100
1999 – 2000 Principal Investigator: Merck & Company Investigation of the “Effect of Losartan on AT1 Receptor Upregulation in the Remodeling Heart”. $37,200
1999 – 2000 Principal Investigator: SmithKline Beecham Investigation of “Carvedilol”. $30,000
2000 – 2005 Principal Investigator: NHLBI RO1: "TNFa regulation of the AT1 receptor and its role in post MI Fibrosis". $1,064,000
2001 – 2003 Mentor for Randy Cowling, Ph.D.: Western States Affiliate of the AHA Postdoctoral Fellowship “Molecular Mechanisms of Cytokine-Induced Upregulation of the AT1 Receptor in Cardiac Fibroblasts.”
2003 – 2005 Principal Investigator: Novartis -Enoxaparin Treatment Post-Myocardial Infarction Inhibits Extra-Cellular Matrix Deposition and Improves Survival. $99,782
2004 – 2006 Mentor for Michikado Iwata, MD: Western States Affiliate of the AHA Postdoctoral Fellowship “Role of Angiotensin – Converted Enzyme 2 and Angiotensin –(1-7) in Cardiac Remodeling After Myocardial Infarction.”
2004 – 2006 Mentor for Xaiowei Zhang, MD: Western States Affiliate of the AHA Postdoctoral Fellowship “Integrins Modulate Cardiac Fibroblast Functions Related to Post-MI Extra-Cellular Matrix Remodeling.”
2005 – Present Co-Investigator: NIA/UCSD - QOL Health Measurement in Patients - Tracking Clinical Outcomes
2005 – 2008 Co-Investigator: 1R21HL080358-01: “Development of Mouse Model to Study Fibroblast Functions”. $424,440.00.
2005 – 2009 Co-Investigator: 1R01HL073355-01A1: “BNP and Neuroimmune Characteristics of CHF and Depression”. $3,008,179.00
2007 – 2010 Co-Investigator: AHA Grant-In-Aid: “Regulation of Ectodomain Cleavage of Angiotensin converting Enzyme 2 and HS Role in Cardiac Remodeling”.
2010 – 2014 Co-Investigator: 1 RO1 HL096784-01A2; “Exploring Tai Chi as a Behavioral Intervention for Heart Failure Patients” $1,926,890.
2009 – 2013 Principal Investigator: I RO1HL091191: “The Mas Receptor is required for the Favorable Effects of Ang-1(1-7) on Cardiac Remodeling”. $1,789,625.
2010 – 2015 Co-Investigator: 5 R01 HL073355-06. “BNP and Neuroimmune Characteristics of CHF and Depression” $2,434,000
2010 – 2015 Co-Investigator: 1 R01 HS019311-01 “Variations in Care: Comparing Heart Failure Care Transition Intervention Effects”
CURRENT UCSD CONTRACT SUPPORT
2005 – 2009 Principal Investigator: Merck & Co. – PROTECT A Randomized, Double-Blind, Placebo-Controlled Study of the Effects of KW-3902IV in Maintaining Renal Function and Improving the Clinical Outcome of Patients with Congestive Heart Failure and Renal Impairment Who Require Hospital Treatment with Intravenous Loop Diuretics for Fluid Overload.
2006 – Present Principal Investigator: Celladon Corporation - A Phase 1, Randomized, Double-Blind, Placebo-Controlled Dose Escalation Trial of Intercoronary Administration of MYDICAR™ (AAV1/SERCA2a) in Subjects with Heart Failure.
2006 – Present Principal Investigator: Celladon Corporation – Assessment of Antibodies to Adeno-Associated Vector Type 1 in Patients with Heart Failure.
2006 – Present Co-Investigator: Amgen – A Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Darbepoetin Alfa Treatment on Mortality and Morbidity in Heart Failure (HF) Subjects with Symptomatic Left Ventricular Systolic Dysfunction and Anemia.
2006 – Present Principal Investigator: Cardiodynamics – Performance Characterization of the BioZ Dx device in Subjects with Cardiac Resynchronization Therapy Devices. Version 1
2006 – Present Co-Investigator: Cardiokine – Lixivaptan versus Placebo in the Treatment of Hyponatremia: A Randomized, Double Blind Trial in Patients with Heart Failure and Volume Overload.
2007 – Present Principal Investigator: Scios – Double-Blind, Placebo-Controlled, Multicenter Acute Study of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure (ASCEND-HF) Protocol No. A 093
2007 – Present Principal Investigator: Cardiodynamics – Prevention of Heart Failure Events with Impedance Cardiography Testing (PREVENT – HF)
2007 – 2009 Principal Investigator: Bayer – Placebo Controlled, randomized, double-blind, Multi-center, multinational Phase IIb study to investigate the efficacy and tolerability of BAY 58-2667 given intravenously in patients with decompensated chronic congestive heart failure. Bay58-2667/12480
2007 – Present Principal Investigator: Corventis – Multi-sensor Monitoring in Congestive Heart Failure Patients.
2008 – 2009 Principal Investigator: Johnson and Johnson – A Randomized, Multicenter Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Rivaroxaban in Subjects with Acute (Open-Label, Active-Controlled) or Chronic (Double-Blind, Placebo-Controlled) Congestive Heart Failure RIVAROXHFA1101/BAY 59-7939-12980
2008 – 2009 Principal Investigator: Cytokinetics – A Phase II, Multi Center, Double Blind, Randomized, Placebo-Controlled, Dose-Escalation, Pharmacokinetic and Pharmacodynamic Study of CK-1827452 in Patients with Stable Heart Failure.
2008 – Present Principal Investigator: Biogen Idec – A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Study to Assess The Effects of Intravenous BG9928 on Body Weight in Subjects with Acute Decompensated Heart Failure and Renal Insufficiency.
2008 – Present Principal Investigator: Biogen Idec – A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Study to Assess the Safety and Tolerability of Oral BG9928 in Patients with Heart Failure and Renal Insufficiency.
2008 – Present Principal Investigator: Nile Therapeutics – A Multicenter, Randomized, Placebo Controlled Phase 2B Study Assessing the Safety and Efficacy of Early Administration of Intravenous SD-NP versus Placebo in the Treatment of Patients with Acute Decompensated Heart Failure (ADHF) – CONDITION HF TRAIL
2008 – Present Principal Investigator: Corthera – A Phase II/III, Multicenter, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Relaxin in Subjects With Acute Heart Failure
2009 – Present Principal Investigator: Johnson and Johnson – A Double-Blind, Placebo-Controlled, Randomized, Ascending IV Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Stresscopin (JNJ-39588146) in Healthy Subjects and Subjects with Stable Heart Failure.
TRAINEES SUPERVISED
1982-83 David Broudy, M.D. - Fellow in Cardiology
1987-89 Howard Lewis, M.D. - Fellow in Cardiology
1988-91 Michael Ontkean, D.O. - Fellow in Cardiology
1989-90 Kishor Vora, M.D. - Research Fellow in Heart Failure/Transplantation
1990-91 Ayokunle Oni, M.D. - Research Fellow in Heart Failure/Transplantation
1993 Dana Bowron - Minority High School Research Apprenticeship Program
1994-97 Jay Ambrose, M.D. - Fellow in Cardiology
1997-98 Johannes Kuiper, M.D. - Fellow in Cardiology
1998 Tina Reyes - Independent Study Project (ISP) for UCSD School of Medicine
1998-99 Juan Alverge – UCSD Undergraduate Independent Research Study Project (BISP) Preceptor
1998-2004 Randy Cowling, Ph.D. - Post-Doctoral Fellow & as of 2000, Postgraduate Researcher
1999-2001 Jian Peng, M.D., Ph.D. – Post-Doctoral Fellow & as of 2000, Postgraduate Researcher
1999-2002 Eduardo Fricovsky – Undergraduate Independent Study Course Work & Research Assistant in NIH Minority Biochemical Research Support Program (MBRS)
2000-2001 John Kjekshus, MD – Visiting Scholar (Sabbatical from Oslo University)
2001-2003 Melanie Reyes – UCSD Undergraduate
2002-Present Michikado Iwata, M.D. – Post-Doctoral Fellow
2002-2005 Xiaowei Zhang, M.D., Ph.D. – Postgraduate Researcher
2002-2004 Ottar Lunde, MD – Visiting Scholar
2002-2004 Alexander Adler, MD – Heart Failure Cardiology Fellow
2004 Vanessa Reese – Brown University Undergraduate for UCSD Medical Scientist Training Program (MSTP) Summer Undergraduate Research Fellowship (SURF)
2004-2005 Myung-A Kim, M.D., Ph.D. – Postgraduate Researcher
2005 Agyenim Amoako – Delaware State University Undergraduate for Summer Undergraduate Research Fellowship (SURF). UCSD Medical Scientist Training Program (MSTP)
2005-2006 Dawn Lombado M.D.-Heart Failure Cardiology Fellow
2005-2007 Reza Kermani – Independent Study Project (ISP) for UCSD School of Medicine (MED 296)
2005 John Kjekshus, MD – Visiting Scholar (Sabbatical from Oslo University)
2007-2008 Keisuke Kida, MD – Post graduate researcher
2008-present Dongheon Yang MD, Ph.D. – Visiting Scholar
2008-present Mi Hyang Kwak , MD, Ph.D., – Visiting Scholar
2010 Ali Evans, Summer Undergraduate Research Fellowship (SURF). UCSD
Medical Scientist Training Program (MTSP).
2010-2011 Payman Zamani MD – Heart Failure Cardiology Fellow
2011-2012 Sami Alim, MD – Heart Failure Cardiology Fellow
CURRENT EDITORIAL BOARDS
Circulation Journal (International Associate Editor 2010 - present)
Congestive Heart Failure (Senior Editor 1995 - present)
Critical Pathways in Cardiology (2008 – present)
European Journal of Heart Failure (2005 - present)
Cardiology Today (2008-present)
US Cardiology (2008-present)
Journal of Geriatric Cardiology (2010-present)
Journal of the American College of Cardiology (Associate Editor 2002 - present)
Journal of the American College of Cardiology (Focus Issue Editor for Quarterly Heart Failure
Focus Issues 2009 - present)
PREVIOUS EDITORIAL BOARDS
American College of Cardiology Current Journal Review (Assistant Editor 1998-2002)
Journal of the American College of Cardiology (1995-1999)
Journal of Cardiac Failure (1998-2004)
Journal of Heart Disease
Journal of Heart and Lung Transplantation (Senior Editor 1994-1999)
INVITED EDITORSHIPS
Section Editor, Current Cardiology Reports “Epidemiology and Pathophysiology of Heart Failure” 4:185-212, May 2002
Guest Editor, Congestive Heart Failure “Neurohormonal Blockade in the Treatment of Heart Failure: Where Do We Go From Here?” 8:245-280, September/October 2002.
Section Editor, Current Cardiology Reports “Epidemiology and Pathophysiology of Heart Failure” 5:181-210, May 2003
Section Editor, Current Treatment Options in Cardiovascular Medicine, “Heart Failure” 5:301-343, August 2003.
Section Editor, Current Treatment Options in Cardiovascular Medicine, “Heart Failure” 5:305-343, August 2004
JOURNAL REFEREE
American Heart Journal
American Journal of Cardiology
American Journal of Physiology
Annals of Internal Medicine
Chest
Circulation
Circulation Research
Drugs
European Journal of Clinical Investigation
Journal of the American College of Cardiology
Journal of Cardiovascular Pharmacology
Journal of Clinical Investigation
Journal of Heart and Lung Transplantation
Proceedings of the Society for Experimental Biology and Medicine
Western Journal of Medicine
ABSTRACT REVIEWER FOR ANNUAL SCIENTIFIC SESSIONS
American Heart Association
American College of Cardiology
Heart Failure Society of America
COMMITTEE PARTICIPATION AND OTHER ACTIVITIES (UCSD)
CME Dean’s Advisory Committee (1995-present)
UCSD Combined Thoracic Organ Transplant Committee (1995-present)
Division of Cardiology Fellowship Applicant Selection Committee (1995-present)
Division of Cardiology Quality Assurance Committee (1995 – present)
Department of Medicine Committee on Appointments and Promotions (DOMCAP)
Member (1996-2003)
Chair (1999-2001)
Immediate Past Chair (2001-2003)
Ad hoc DOMCAP Committee member (2009)
School of Medicine Ad Hoc Committee on Appointments and Promotions (CAP)
Chair, Ad Hoc Committee on Appointments and Promotions (June, 1997, March, 2001)
Chair, UCSD School of Medicine Committee for Review of Radiology Department Leadership (May 2012)