98 East Evangeline Oaks CIR

WENFU WANG

98 East Evangeline Oaks CIR

The Woodlands, TX 77384

Phone: (936) 271-3595 (Home),

(713) 745-4703 (Work),

______

Education:

University of Houston, M. Sc. 2001 Computer Science

University of Houston, Ph.D. 1996 Molecular Genetics

Institute of Genetics, Academia Sinica, Beijing, M. Sc. 1988 Genetics

Beijing Normal University, Beijing, BS 1985 Biology

Professional Certification:

Microsoft Dot.Net Boot Camp2004

MCSD (Microsoft Certified Software Developer) 2000

Sun Certified Java 1.2 programmer 2000

SQL Server Certification by CTREC 2001

Employment History:

Programmer Analyst III, 2001/4 –Present

M.D. Anderson Cancer Center

Houston, TX 77030-4095

Programmer Analyst II, 1999/8 –2001/4

M.D. Anderson Cancer Center

Houston, TX 77030-4095

Research Associate, 1996-1998

Baylor College of Medicine

Houston, TX 77030

Teaching/Research Assistant, 1992-1996

University of Houston

Houston, TX

Research Assistant, 1988-1992

Institute of Genetics

Academia Sinica, Beijing, China

Professional Experience :

Program Analyst, MD Anderson Cancer Center, 1999-present

• Consulting

Provided a one time consulting service to Ellipsis biotherapeutics Corp (Canada)

for its bioinformatics infrastructures primarily on laboratory information management

system.

• Database Management Application Development

Designed and implemented a lab information system for the TARGET project

(Oracle and VB6.0).

Conducted system analysis and developed several lab specimen management database

applications to satisfy different lab’s requirements (MS Access and VBA).

Designed and constructed a database to store high throughput genotype data for RA (Rheumatoid Arthritis) genome scan project (Implemented in SQL server 7.0).

Modified a database application for collecting Brain Tumor patient data through questionnaire survey. (VB 6.0 and MS Access)

• Other Software Development Projects

Developed a patient data transfer application to facilitate the data exchange between MD Anderson and former Genometrix Inc. (Implemented in JAVA, Oracle, and MS Access).

Developed PERL program modules to facilitate monthly data upload to Patient History Oracle Database from DB2 database.

Developed a database dictionary generator application to facilitate documenting and analyzing the data elements in the database (in JAVA)

Developed C and PERL programs that implement statistical related algorithms for genetic linkage analysis.

Developed a chromosome viewer application that render all the human chromosomes with correct banding patterns and all the associated abnormalities through parsing differential genomic hybridization data. (OpenGL, C++).

• Data Analysis

Developed an automation procedure for mutation detection through sequence chromatogram analysis. (Using GCG, BLAST, FASTA as well as FRED, PHRAP, CONSED, VBA, PERL etc.).

Performed Association study between LOH (Loss of heterozygosity) of biomarkers and

Wilms tumor suppressor gene WT1 mutations. This project was to test possible

association between LOH (Loss of heterozygosity) of biomarkers and Wilms tumor

suppressor gene WT1 mutations (SAS, S-Plus, MS Access and VBA).

• Web projects

Maintained the web site for Peutz-Jeghers study project (HTML)

Developed a PERL based counter for CGN web page.

Developed a WWW E-mail module (PHP).

Research Associate, Baylor College of Medicine, 1996-1998

• Biomedical Research, Computational Molecular Genetics

Activities involved were searching and retrieving data from public database GenBank as well as SwissProt, and PIR etc; analyzing thedata through different application software such as MacVector, DNA Star and phylogenic analysis packages; managing data conversion with different format and in different OS (Mac, PC and Unix). The results obtained through these computational approaches are directly used to guide biomedical research. Other activities include experimental design, performing experiments related to signal transduction.

Teaching and Research Assistant, University of Houston, 1992-1996

• Teaching as a teaching assistant

General Biology 1-2

Microbiology

Human Anatomy and Physiology

• Web management

Functioned as web Master and web Administrator for the Institute for Molecular Pertinacity. Activities involved were MacTCP configuration through AppleTalk network; Static VS Dynamic IP address configuration; Installation and configuration of HTTP server.

• Bio-Computing / Data Management

Activities involved were DNA/protein sequence analysis through programs such as Blast/Fasta, GCG package and Entrez. These computational approaches along with others result in a successful cloning and identification of a gene as "14-3-3" which is deposited in GenBank database ( In addition, a 14-3-3 DNA/protein sequence database was constructed and analyzed with several molecular evolutionary analysis software, which resulted in a publication (J of Mol Evol, 1996

Research Assistant, Institute of Genetics, Academia Sinica, Beijing, 1988-1992

Research in genetics

Computing skills:

Programming Languages:

C#, VB.Net, ASP.Net, C/C++, Visual Basic 5/6, Visual C++, Java 1.1/Java 1.2, Perl,

CGI, HTML4.0, XML, Assembly (Intel 8086), Unix shell scripts, JavaScript, VbScripts,

Cold Fusion, Structured Query Language (SQL), Lex and Yacc, Fortran, ASP and JSP,

PHP, COM/DCOM, OpenGL, Parallel Computing (MPI and HPF).

Database:

Database Modeling, Designing and Application developing with commercial RDBMS

systems: Microsoft SQL server 7.0, Oracle 8.0/7.X, MySQL and Microsoft Access 97.

Other Database Application Systems: ACEDB.

Operating system:

BSD Unix, Solaris, System V Unix, AIX, Linux, Window 2000,Window NT, Windows

98, Windows 95, MS-DOS, X window, VMS/VAX, MacOS, IBM, QBF

Applications: Microsoft Office, SAS. SPSS, S-Plus, Adobe PhotoShop, Cricket Graph,

MatLab, MacDraw Pro, Canvas, MacVector, DNAID, DNA Strider and DNA Star etc.

Honors and Awards:

6/1995 Travel award to meeting from C. elegans Conference Committee

6/1994 Departmental travel award to the worm meeting (UH, Biology)

4/1994 Sigma XI grant for research

5/1993 Best teaching evaluation in the department (UH, Biology)

6/1992 Departmental research excellence fellowship (UH)

7/1985 Excellent Student Award (Biology Dept., Beijing Normal U)

Publications:

Amos CI, Frazier ML, Wang W 2000 DNA Pooling in Mutation Detection with

Reference to Sequence Analysis. Am J Hum Genet 66(5):1689-1692

Chen YR, Wang WF, Kong ANT and TH Tan 1998 Molecular Mechanisms of c-Jun

N-terminal Kinase-mediated Apoptosis induced by anticarcinogenic

isothiocyanates. J. Biol. Chem. 273: 1769-1775

Wang WF, Zhou G, Hu, M C.-T, Yao Z and TH Tan 1997 Activation of the

HPK1-dependent, stress-activated JNK pathway by TAK1, A kinase mediator of

TGF-beta signal transduction. J. Biol. Chem. 272: 22771-22775

Wang WF and Shakes DC 1997 Expression patterns and transcript processing

of FTT-1 and FTT-2, two C. elegans 14-3-3 homologues. J of Molecular Biology 268:

619-630

Wang WF and Shakes DC 1996 Molecular evolution of 14-3-3 protein family

J of Molecular Evolution 43:384-398

Wang WF and Shakes DC 1994 Isolation and sequence analysis of a

Caenorhabditis elegans cDNA which encodes a 14-3-3 homologue. Gene 147:215-218

Wang WF , Chen Z.H. etc 1991 Protocorm proliferation and the study of

artificial seeds of tropical orchids In:Guo Z.S.(ed) "Plant somatic

embryogenesis and artificial seed

Science press Beijing pp 112-117 (In Chinese with English abstract)

Yao YG, Chen ZH, Wang WF, Zhang LH and Liu GZ 1991 Studies on the

artificial seeds by encapsulating regenerated shoots of Eucalyptus

camaldulensis In:Guo Z.S.(ed) "Plant somatic embryogenesis and artificial

seed Science press Beijing pp 122-126 (In Chinese with English abstract)

Wang WF and Chen Z.H. 1990 Somatic embryogenesis and preliminary study of

artificial seeds in Brassica spp In: Chen and Redenbaugh(ed)"Artificial Seeds

" High Education Press Beijing pp119-128 (In Chinese)

Yao YG. Chen ZH, Zhang LH, Wang WF and Liu GZ 1990 Morphogenesis of In

vitro cultured Eucalyptus leaves and the artificial seed study In: Chen

and Redenbaugh(ed)"Artificial Seeds " High Education Press Beijing

pp99-110 (In Chinese)

Chen ZH, Cun SX, Chen ZZ, Zhang DW, Wang WF and Li WB 1989 Obtaining new

variety of rape by biotechnology In: Lyama S.(ed) Breeding Research: The

key to the survival of the Earth pp 505-509