Module 1. Analysis of the quality of drug substances of inorganic nature and aliphatic organic compounds that are used as components of pharmaceuticals.
1. This reagent AgNO3 can be used for limit test for such impurity:
- *Chlorides
- Magnesium and alkaline earth metals
- Heavy metals
- Sulphates
- Phosphates
2. This reagent K2[HgI4] can be used for limit test for such impurity:
- Arsenic
- Zinc
- Heavy metal
- *Ammonium
- Calcium
3. This reagent K4[Fe(CN)6] can be used for limit test for such impurity:
- Arsenic
- *Zinc
- Heavy metal
- Aluminium
- Calcium
4.For limit test for Heavy metals use such reagent:
- Potassium iodide
- *Thioacetamide
- Barium chloride
- Ammonium oxalate
- Silver nitrate
5. Initial standard substance for preparation of standard solution of Potassium is:
- *Potassium sulphate
- Potassium hydroxide
- Potassium nitrate
- Potassium acetate
- Potassium chloride
6. For limit test for Chlorides use such reagent: silver nitrate solution R2 in presence of dilute nitric acid R. What analytical effect of reaction?
- Brown solution
- Red precipitate
- Black solution
- Green precipitate
- *Opalescence
7. For limit test for Arsenic (method B) use such reagent: KI, HCl, NaH2PO2. What analytical effect of reaction?
- *Brown solution
- White precipitate
- Black solution
- Green precipitate
- Opalescence
8. Specific impurities get to medicinal substances:
- From packing materials
- *At obtaining and storage
- From equipment
- From air
- At transportation
9. For limit test for Arsenic (method A) use filtering paper impregnated with a solution:
- Potassium iodide and starch
- Tin (II) chloride
- *Mercury (II) bromide
- Lead acetate
- Silver nitrate
10. For limit test for Calcium use such reagent:
- Mercury (II) bromide
- Silver nitrate
- Potassium ferrocyanide (II)
- Sodium sulphide
- *Ammonium oxalate
11. For limit test for Sulphates use such reagent:
- Silver nitrate
- Potassium ferrocyanide (II)
- Potassium ferricyanide (III)
- *Barium chloride
- Ammonium oxalate
12. According to requirements SPU, research of intensity of colouring of liquids spend:
- Looking samples on a matte black background
- *In reflected light, looking samples horizontally (it is perpendicular to an axis of test tubes) on a white background
- In diffused artificial light on a white background
- In diffused daylight on a black background
- At artificial light on a black background
13. To reactions, which are used at definition of the limiting content of impurity in medicinal substances, the requirement does not concern:
- The reaction outer effect should be observed through a short time interval
- Stoichiometric
- High sensitivity
- *Exothermic
- Selectivity
14. To reactions, which are used at definition of the limiting content of impurity in medicinal substances, the requirement does not concern:
- *Exothermic
- Stechiometric
- High sensitivity
- The reaction outer effect should be observed through a short time interval
- Selectivity
15. For definition of the limiting content of impurities in drugs the pharmacist-analyst uses:
- Solutions of reducers
- Buffer solutions
- *Standard solutions
- Titrated solutions
- Solutions of concentrates
16. For limit test for Iron use such reagents:
- Potassium ferrocyanide (II)
- Barim chloriden in the acid medium
- Potassium ferricyanide (III)
- Ammonium rhodanide (thiocyanate)
- *Citric acid R and thioglycollic acid R with the next alkalizing an ammonia solution R
17. For limit test for Calcium use such reagent:
- *(NH4)2C2O4
- AgNO3
- H2S
- K4[Fe(CN)6]
- Na2S
18. According to requirements SPU, research of opalescence degree spend:
- Looking samples on a matte black background
- looking samples on a matte white background
- In a diffused light on a white background
- *In a diffused daylight, on a black background
- At artificial light on a black background
19. For limit test for Arsenic (method B) use such reagents:
- FeCl3, HCl, H2O
- (NH4)2C2O4, CH3COOH, H2O
- *KI, NaH2PO2, HCl
- H2O, AgNO3, HNO3
- BaCl2, CH3COOH, H2O
20. For limit test for Ammonium (method A) use such reagent:
- Feling
- *Nessler
- Dragendorf
- Tollens
- Mark
21. Solutions, which contain chlorides-ions, depending on percentage, form with a silver nitrate solution in the presence of nitrate acid diluted a white curdy precipitate, cloud or opalescence, which easily disappear from addition:
- An alkali solution
- Waters cleared
- A solution of sulphate acid
- A solution of sodium acetate
- *An ammonia solution
22. Impurities of ions NH4+, Zn2 +,Cl-, SO42 - are characteristic for:
- Any group
- Substances of inorganic drugs
- Substances of drugs of separate pharmacological group
- *Practically all substances of drugs
- Separate substances of organic drugs
23. For limit test for Sulphates use:
- Absence of standart solution
- Standart solutions
- A standart solution alcoholic
- *Distilled water R
- Water R
24. Copper sulphate is used in medical practice as agent:
- *Antiseptic, caustic, astringent
- Adsorbent
- Hypnagonue, hemostatic
- Antihypertensive, purgative
- Antiallergic, antiacid, anti-inflammatory
25. The method of assay for copper sulphate is iodometry, substitute titration.As titrant use:
- Starch solution
- Iodine
- *Sodium thiosulphate
- Potassium iodide
- Iodo-chlorine
26.What observed chemist at identification of Bismuth cation in the acidified solution of bismuth nitrate basic by means of sodium sulphide?
- *Formation of brown precipitate
- A solution of yellow colour
- Solution cloudiness (turbidity)
- Formation of white precipitate
- Hydrogen sulphide allocation
27.For identification of Magnesium cations in the magnesium oxide light, according to requirements SPU, after dissolution in the chloride acid it is necessary to add such reagents:
- Zincuranylacetate in acetic-acid medium
- Ammonium oxalate in acetic-acid medium
- Solutions of silver nitrate and HNO3
- Sodium cobaltinitrite; tartaric acid at presence sodium carbonate
- *Solutions NH3 diluted, chloride ammonium, disodium hydrophosphate
28.What substance is the weight form in the gravimetric analysis at definition of Magnesium cations in the magnesium sulphate heptahydrate (precipitation makes by means of ammoniac solution of disodium hydrophosphate)?
- Magnesium orthophosphate
- *Magnesium-ammonium phosphate
- Magnesium hydroxide
- Magnesium pyrophosphate
- Magnesium oxide
29.In the medical practice calcium chloride hexahydrate use:
- Intramuscularly 10 % a solution
- Hypodermically (subcutaneously) 5–10 % a solution
- *Intravenously 10 % a solution
- Oral in the form of tablets
- Oral in the form of a powder
30.The method of assay for calcium chloride hexahydrate is chelatometry (direct titration). As titrant use standard solution of:
- *Sodium EDTA
- Lead nitrate
- Silver nitrate
- Sodium hydroxide concentrated
- Chloride acid
31.At assay of copper sulphate by means of iodometry can be used such indicator:
- Lacmus
- *Starch solution
- Xylenol orange
- Methyl orange
- Phenolphtalein
32.For identification of zinc sulphate heptahydrata it is necessary to spend reactions with:
- Barium chloride
- Methoxyphenylacetic acid reagent
- Feling reagent
- *Potassium ferrocyanide (ІІ)
- Nessler reagent
33. Synonyms of zinc sulphate are names:
- *Zinc vitriol (copperas)
- Red vitriol (copperas)
- Green vitriol (copperas)
- Copper vitriol (Blue copperas)
- Iron vitriol (yellow copperas)
34.Under the description calcium chloride dihydrate is:
- Red crystalline powder, hygroscopic
- Green amorphous powder
- Yellow crystalline masss
- *White crystalline powder, hygroscopic
- Amorphous blue masss or powder
35.What analytical effect of reaction chloride acid with magnesium carbonate heavy?
- A white smoke
- *Liberation of gas bubles
- Allocation of brown steams
- Formations of a white precipitate
- Formations of a yellow precipitate
36.Assay of calcium chloride hexahydrate makes by means of chelatometry (direct titration). The equivalent weight (Em) of a preparation is:
- М m./3
- М m./4
- *М m.
- 2М. M.
- М m./2
37.What reagents use for revealing of anions in a substance of copper sulphate?
- A solution of potassium permanganate
- A solution of mineral acid
- Solution of NH3 concentrated
- *Barium chloride and НCl
- Silver nitrate and НNO3
38.For identification of zinc sulphate heptahydrata it is necessary to spend reactions with:
- Barium chloride
- Nessler reagent
- Methoxyphenylacetic acid reagent
- Feling reagent
- *Sodium hydroxide and sodium sulphide
39.For identification of cations of Magnesium in a substance of magnesium carbonate light it is possible to use such reagents:
- A solution of silver nitrate in the medium of НCl
- Barium chloride and chloride acid
- Tartaric acid
- Diphenylamine in the concentrated Н2SO4
- *Quinalizarin alcoholic solution in the presence of alkali
40.Which metal be used for making the plate (lamina), if at interaction with copper sulphate it becames with red blush:
- Radon
- *Iron
- Sulphur
- Platinum
- Silver
41.Bismuth nitrate basic in medical practice use as agent:
- Antiseptic, caustic
- Adsorbent and coating ability
- Hypnagonue, hemostatic
- *Astringent, antiseptic
- Antiallergic, anti-inflammatory
42.What formula of basic magnesium carbonate?
- Mg(OH)2
- *3MgCO3•Mg(OH)2•3H2O
- MgCO3
- MgO
- Mg(HCO3)2
43.For identification of cations of Magnesium in a substance of magnesium carbonate light it is possible to use such reagents:
- A solution of silver nitrate in the medium of НCl
- Barium chloride and chloride acid
- Tartaric acid
- Diphenylamine in the concentrated Н2SO4
- *A solution of 8-oxyquinoline in the medium of ammonia buffer solution
44.Pharmacopoeial method of assay for calcium chloride dihydrate is:
- *Chelatometry
- Alkalimetry
- Mercurimetry
- Oxalatometry
- Argentometry (Morh method)
45.The method of assay for copper sulphate is iodometry, substitute titration. As titrant use:
- KI
- ICl
- *Na2S2O3
- NaIO
- I2
46.What analytical effect reaction ammonia solution with copper sulphate solution?
- *A blue precipitate, which is dissolved a lot of reagent
- A white precipitate, which is dissolved a lot of reagent
- Precipitate of red colour
- Liberation of gas
- Occurrence of cloud (turbidity)
47.What component of inorganic drugs not have oxidation-reduction properties:
- AsО2-
- NO2 -
- MnО4-
- AsО43-
- *Zn2 +
48.As drug use such compouns of Calcium:
- Calcium nitrate
- Calcium sulphite
- Calciumphosphate
- Calciumfluoride
- *Calciumchloridedihydrate
49.The molar mass of an equivalent (Em) of Magnesium salts in the chelatometry is:
- М m./3
- *М m.
- М m./4
- 2М. M.
- М m./2
50.Pharmacopoeial reaction for Calcium cation is reaction with:
- Glycerine
- *Glyoxalhydroxyanil alcoholic solution
- Alizarin
- Mineral acid
- Alkali
51.As drug use such compouns of Calcium:
- Calcium nitrate
- Calcium sulphite
- Calciumphosphate
- Calciumfluoride
- *Calciumchloridehexahydrate
52.To zinc chloride add potassium dichromate and sulphate acid. What analytical effect reaction?
- Formation of a white precipitate
- *Allocation of chlorine and colouring change
- Occurrence of dark blue colour
- Occurrence of orange colour
- Solution decolouration
53.What inorganic compounds are initial for reception of copper sulphate?
- *Copper, concentrated sulphate and nitrate acids
- Copper hydroxide, sulphite acid
- Copper oxide, water
- Copper, chloride acid
- Copper chloride, nitrate acid
54.What method can be used for assay of zinc chloride?
- Non-aqueous titration
- Gravimetry
- Cerimetry
- *Chelatometry
- Argentometry
55.The water solution of copper sulphate has reaction * owing to process (2):
- 1. Neutral. 2. Hydrolysis
- 2. Alkaline. 2. Substance decomposition
- *1. Acid. 2. Hydrolysis
- 1. Acid. 2. Electrolytic dissociation
- 1. Acid. 2. Electrolysis
56.By means of chelatometry it is possible to define preparations, which contain cations two-, three- and four-valent metals. Molar weight of an equivalent (Em) at assay of the given preparations is:
- *М m.
- М m./3
- М m./4
- 2М. M.
- М m./2
57.What is the weight form at gravimetric definition of magnesium carbonate heavy?
- Magnesiumchloride
- Magnesiumsulphate
- *Magnesiumoxide
- Magnesiumcarbonate
- Magnesiumhydroxide
58.What drug is possible obtain by means of reaction calcium carbonate with chloride acid?
- Carbondioxide
- Oxygen
- *Calciumchloride
- Calciumoxide
- Lime chloride
59.What characters of magnesium oxide heavy?
- White liquid
- Blue crystalline powder, soluble in water
- Yellow fine crystalline powder, soluble in water
- *White fine crystalline powder, practically insoluble in water
- White fine amorphus powder, practically insoluble in water
60.Adsorptive capacity of absorbent coal define on solution decolouration:
- Methyl orange
- Fuchsine
- *Methylene dark blue
- Iodine
- Potassium permanganate
61.What reaction use for identify impurity of cyanides in the absorbent coal:
- An iodine solution
- Ammonia
- H2SO4, iron(ІІ) sulphate, HCl
- H2SO4, NaOH, AgNO3
- *H2SO4, NaOH, Fe2(SO4)3, FeCl2
62.At gravimetric method of assay (quantitative definition) of Al(OH)3 weight (gravimetric) form the preparation is:
- Al2(SO4)3
- AlCl3
- Al(NO3)3
- *Al2O3
- Al (OH)3
63.Gastal tablets containes of Al(OH)3,МgCO3 and MgО. Pharmacopoeial reaction of Al(OH)3 identification is reaction with NaOH solution after dissolution with acid. What analytical effect of reaction?
- Liberation of gas
- Formation of black precipitate
- Formation of a yellow precipitate
- Formation of a white curdy precipitate
- *Formation of white precipitate
64.What reagents necessary for revealing of barium soluble salts and barium carbonate in the substance of barium sulphate:
- CH3COOH, HCl
- Na2CO3, HCl
- *CH3COOH, H2SO4
- CH3COOH, Na2S
- H2SO4, Na2S
65.What reagens are necessary for reaction “silver mirror” - reaction for Ag+-ions in the substance of AgNO3?
- Solution of NaOH; barium chloride solution
- *Formaldehyde and ammonia solutions; solutions of chloride and nitrate acids
- diphenylamine solution in the concentrated H2SO4
- Formaldehyde and acetic acid
- Formaldehyde and nitric acid
66.The method of assay for Al(OH)3 is:
- Iodometry
- Polarimetry
- *Gravimetry
- Mercurimetry
- Argentometry
67.Pharmacopoeial reaction for aluminium hydroxide substance is:
- Reaction with ammonium sulphide
- *Reaction with solution of NaOH after dissolution in acid
- Reaction with alizarin
- Reaction with 8-oxyquinoline
- Formation of “Thenard's blue”
68.Aluminium in the nature is in:
- Is not anywhere
- To vegetative raw materials
- Water resources
- Air
- *The earth crust
69.In the medical practice absorbent coal use as agent:
- Anticonvulsant
- Antifussic
- *Adsorbend
- Antiacid
- Anaesthetic
70.The inadmissible impurities in the absorbent coal is:
- Hydroxides
- *Cyanides
- Sulphates
- Carbonates
- Sulphides
71.Carbon dioxide is a part of a medical drug:
- Lime chloride
- Nitrogen(I) oxide
- Sodium hydrocarbonate
- *Carbogenum
- Absorbent coal
72.The preparations of Arsenic store in the drugstore:
- A selling area, near to a cash register
- *In accordingly issued safe or a metal case under lock and key
- A basement, in a separate room
- An the separate premise, according to pharmacological groups
- An the management office of a chemist's shop, under lock and key
73.Initial substance for obtaining silver nitrate are:
- AgCl and NO
- *Ag and HNO3
- Ag and HNO2
- Ag and N2O
- AgNO2 and O2
74.Barium sulphate is used in medical practice for roentgenoscopy:
- Nephrous
- *Gastrointestinal tract
- Gall duct.
- Blood vessels and heart
- Blood vessels of brain
75.What chemical compounds use for obtaining of barium sulphate?
- Solutions of BaСl2 and Na2S
- Solutions of Ba(OH)2 and Na2S
- *Solutions of BaCl2 and Na2SO4
- Solutions of BaCO3,Na2SO3
- Barium, H2S
76.What reagents can be applied for difference arsenit-anions an arsenat-anions?
- Potassium hexahydroxostibat
- *АgNO3; iodine in the presence of NaHCO3
- Baium chloride, CH3COOH
- Diphenylamine in the concentrated sulphate acid
- Barium chloride; concentrated H2SO4
77.Assay of Na2HAsО4, acidified by chloride acid, makes by means of method:
- Alkalimetry
- Permanganatometry
- Argentometry
- *Iodometry (substitute titration)
- Acidimetry
78.Carbon dioxide identify by means of passing it through:
- Lime chloride
- Silver nitrate
- Bromine water
- Distilled water
- *Lime water
79.Absorbent coal is active ingredient of:
- Gutalax
- Enterosgel
- Sorbigel
- *Carbolenum
- Carbolong
80.What properties are characteristic for Aluminium and its compounds?
- Oxidation
- *Amphoteric
- Oxidation-reduction
- Basic
- Acid
81.What reagens are used by the expert for identification of barium sulphate?
- Na2S, Na2CO3, BaCl2, HCl, H2SO4
- *Na2CO3, HCl, BaCl2, H2SO4
- BaCl2, Na2CO3, HCl
- Na2CO3, Na2S, HCl, H2SO4
- Na2CO3, HCl, H2SO4
82.Silver nitrate is used in medical practice as agent:
- Anaesthetic and antipyretic
- Demulcent and antipyretic
- *Antiseptic and caustic
- Antiseptic and hemostatic
- Anaesthetic and caustic
83.Bariumsulphate is used in medical practice oral in quantities until 100 g. What of enumerated below requirements will be must correspond a preparation?
- Dissolved in chloride acid diluted
- High degree of cleanliness
- *Corresponding sedimentation rafe
- Etalon turbidity ІІ
- Etalon turbidity І
84.What method of assay for aluminium hydroxide is the most exact?
- Non-aqueous titration
- *Gravimetry
- Mercurimetry
- Chelatometry
- Neutralization
85.As a medical drug use:
- Aluminium carbonate
- Aluminium chloride
- *Aluminium hydroxide
- Aluminium sulphate
- Aluminium oxide
86.Potassium cations in the KAsO2 it is possible to identify, use such reagents:
- Zincuranylacetate in acetic acid medium; glyoxalhydroxyanil alcoholic solution
- Ammonium oxalate in acetic acid medium; quinalizarin
- Sodium hydrogenphsphateт in the medium of ammonia buffer solution; a solution of silver nitrate
- *Sodium cobaltinitrite; tartaric acid at presence sodium carbonate
- An alkaline solution of potassiumtetraiodomercurat; 8-oksihinolin
87.The toxicity reason of Arsenic compounds on organism is:
- *Binding of HS-groups of fermental proteins
- Binding of H2N-groups of protein molecules
- Formation of insoluble compounds
- Infringement (disorder, disturbance) of tissue respiration
- Change ion structure of biological liquids
88.One gramme of absorbent coal has an inside face (internal surface) nearby:
- 200 м2
- 500 м2
- *1000 м2
- 10 м2
- 100 м2
89.Absorbent coal receive as a result of processing of wood or animal coal:
- Chlorine
- An ammonia solution
- Sodium hydroxide
- *Superheated water steam
- Chloride acid
90.Concentrated hydrochloric acid contains:
- 15.0 to 20.0% of HCI
- *35.0 to 39.0% of HCI
- 20.0 to 25.0% of HCI
- 9.5 to 10.5% of HCI
- 6.0 to 7.0% of HCI
91.0,3-0,5% solution of HCl use as agent:
- Antiviral
- *Regulator of metabolic process
- Antiarrhytmic
- Antiacid
- Anticancer
92.For assay of dilute hydrochloric acid can be used argentometry (Volhard method), back titration. What colour of test solution in the equivalent point?
- Any colour
- Orange
- Blue
- *Red-pink
- White
93.For assay of dilute hydrochloric acid can be used argentometry (Volhard method), back titration. As indicator use:
- *Iron(III) ammonium sulphate
- Eosine
- Potassium chromate
- Starch solution
- Methyl red
94.For assay of dilute hydrochloric acid can be used argentometry (Volhard method), back titration. As titrant use:
- Iron(III) thiocyanate
- *Ammonium thiocyanate
- Silver thiocyanate
- Silver nitrite
- Silver nitrate
95.What characters of dilute hydrochloric acid?
- Colorless gas
- *Colorless, clear, fuming liquid
- White crystalline powder
- Colorless crystalline powder
- Yellow crystalline powder
96.What method of synthesis HCl?
- Any method
- Synthesis from NH4OH and NaCl
- Decomposition of NH4Cl
- *Synthesis from gas H2 and Cl2 and the next saturated of H2O
- Synthesis from NH4NO3 and NaCl
97.Dilute hydrochloric acid as drug is strongly acid. Its pH is:
- рН р 5,5
- рН р 10
- *рН р 1
- рН р 7
- рН р 4
98.What analytical effect of reaction NaHCO3 with saturated solution of MgSO4 at boiling?
- Red gas
- Green precipitate
- Yellow gas
- Black solution
- *White precipitate
99.For assay of boric acid as indicator use:
- *Phenolphthalein solution
- Potassium chromate solution
- Eosine solution
- Methyl red solution
- Tropeolin 00 solution
100.Boric acid is:
- A yellow solution
- *A white, crystalline powder, colourless, shiny plates greasy to the touch, or white crystals, soluble in water and in alcohol, freely soluble in boiling water and in glycerol
- A grey, crystalline powder soluble in toluene and in ester
- A colourless solution
- A yellow, crystalline powder bed soluble in water and in alcohol
101.An assay of boric acid is performed in the medium of (according to Pharmacopoeia):
- Ether
- Ethanol
- Methanol
- Glycerin
- *Mannitol
102.For assay of HCl as indicator use:
- Potassium chromate solution
- Eosine solution
- *Methyl red solution
- Starch solution
- Tropeolin 00 solution
103.What method of assay for NH4OH?
- Iodometry, direct titration
- Chelatometry, direct titration
- Argentometry, direct titration
- Argentometry, back titration
- *Acidimetry, back titration
104.For identification of HCl use reactions with:
- Magnesium oxide
- Salts of heavy metals
- *Solution of silver nitrate
- Potassium permanganate in water solution
- Solution of bromine
105.For assay of borax as indicator use:
- Potassium chromate
- Eosine solution
- Methyl red solution
- *Phenolphthalein solution
- Methyl orange solution
106.For assay of HCl use:
- Ion-exchange chromatography
- *Titrimetric method with sodium hydroxide
- Titrimetric method with silver nitrate
- Spectrophotometry
- Gravimetric method based on reaction with silver nitrate
107.For identification of borax use: