Sample / Follow-up
(years) / Baseline age (years) / Outcome / Dementia criteria / Total number of dementia cases / Dementia subtypes / MCI severity (SD) / Number classified as MCI at baseline / Definition and modifications / Sensitivity / Specificity / AUC
Eugeria Longitudinal Study of Cognitive Aging, France1 / 2 / 60 / Dementia / DSM-III-R / 19 / - / 1.5 / 23 / Mayo Clinic: A-MCI / 5 / 91 / 0.48
1.5 / 139 / Stockholmconsensus: MCIr / 95 / 66 / 0.80
1.5 / 63 / Stockholmconsensus: predominately nonamnestic MCIr / 23 / 30 / 0.26
1.5 / 76 / Stockholmconsensus: predominately anmestic MCIr / 77 / 70 / 0.73
Maastricht Aging Study (MAAS), Netherlands2 / 3 / 60 / Dementia / DSM-III-R,DSM-IV andguidelines of the general practice / 44 (n=13 in first 3years) / Clinical judgement and NINCDS-ADRDA (13 VaD, 31 pro-AD) / 1.5 / 11 / Mayo Clinic: A-MCI / 8 / 98 / 0.53
1.5 / 20 / Mayo Clinic: M-MCI / 8 / 97 / 0.52
1.5 / 173 / Mayo Clinic: R-MCI, without the requirement of SMC / 54 / 74 / 0.64
1.5 / 58 / Mayo Clinic: R-MCI, with the requirement of SMC / 23 / 92 / 0.57
3–9 / 1.5 / 11 / Mayo Clinic: A-MCI / 14.0 / 99.0 / 0.56
1.5 / 20 / Mayo Clinic: M-MCI / 24.0 / 97.0 / 0.61
1.5 / 125 / Mayo Clinic: R-MCI, without the requirement of SMC / 66.0 / 78.0 / 0.72
1.5 / 45 / Mayo Clinic: R-MCI, with the requirement of SMC / 31.0 / 93.0 / 0.63
1.5 / 89 / Mayo Clinic: R-MCI, with proxy informant report of decline / 59.0 / 84.0 / 0.70
3-9 / 1.5 / - / Mayo Clinic: A-MCI (age corrected: 60–70years) / 0.0 / 99.0 / 0.50
1.5 / - / Mayo Clinic: A-MCI (age corrected: 70–85years) / 20.0 / 98.0 / 0.59
1.5 / - / Mayo Clinic: M-MCI (age corrected: 60–70years) / 0.0 / 98.0 / 0.49
1.5 / - / Mayo Clinic: M-MCI (age corrected: 70–85years) / 35.0 / 96.0 / 0.66
1.5 / - / Mayo Clinic: R-MCI, without the requirement of SMC (age corrected: 60–70years) / 56.0 / 83.0 / 0.69
1.5 / - / Mayo Clinic: R-MCI, without the requirement of SMC (age corrected: 70–85years) / 70.0 / 73.0 / 0.71
1.5 / - / Mayo Clinic: R-MCI, with the requirement of SMC (age corrected: 60–70years) / 0.0 / 95.0 / 0.48
1.5 / - / Mayo Clinic: R-MCI, with the requirement of SMC (age corrected: 70–85years) / 31 / 93 / 0.69
1.5 / - / Mayo Clinic: R-MCI, with proxy informant report of decline (age corrected: 60–70years) / 57.0 / 88.0 / 0.72
1.5 / - / Mayo Clinic: R-MCI, with proxy informant report of decline (age corrected: 70–85years) / 55.0 / 820 / 0.69
Leipzig Longitudinal Study of the Aged (LEILA75+), Germany2 / 3(mean2.6) / 75 / Dementia / DSM-IV / 89 / DSM-IV (60 AD, 15 VaD, 14 other) / 1.0 / 29 / Mayo Clinic: A-MCI / 10.1 / 97.6 / 0.54
1.0 / 47 / Mayo Clinic: A-MCI, without the requirement of SMC / 11.2 / 95.5 / 0.53
1.0 / 82 / AACD / 37.1 / 95.2 / 0.66
1.0 / 183 / AACD, without the requirement of SMC / 61.8 / 87.4 / 0.75
Leipzig Longitudinal Study of the Aged (LEILA75+), Germany4 / 3 (mean2.6) / 75 / Dementia / DSM-IV / 89 / DSM-IV (60 AD, 15 VaD, 14 other) / 1.5 / 23 / Mayo Clinic: A-MCI / 13.5 / 98.7 / 0.56
2.0 / 17 / Mayo Clinic: A-MCI / 10.1 / 99.0 / 0.55
1.5 / 39 / Mayo Clinic: A-MCI, without the requirement of SMC / 14.6 / 97.1 / 0.56
2.0 / 29 / Mayo Clinic: A-MCI, without the requirement of SMC / 12.4 / 97.9 / 0.55
1.0 / 53 / Non-Mayo Clinic: CI-Multi / 15.7 / 95.4 / 0.56
1.5 / 17 / Non-Mayo Clinic: CI-Multi / 3.4 / 98.3 / 0.51
2.0 / 5 / Non-Mayo Clinic: CI-Multi / 1.1 / 99.5 / 0.50
1.0 / 112 / Non-Mayo Clinic: CI-Multi, without the requirement of SMC / 27.0 / 90.0 / 0.59
1.5 / 31 / Non-Mayo Clinic: CI-Multi, without the requirement of SMC / 9.0 / 97.4 / 0.53
2.0 / 10 / Non-Mayo Clinic: CI-Multi, without the requirement of SMC / 4.5 / 99.2 / 0.52
1.0 / 57 / Non-Mayo Clinic: CI-NonA, with subjective report of cognitive decline / 10.1 / 94.5 / 0.52
1.5 / 39 / Non-Mayo Clinic: CI-NonA, with subjective report of cognitive decline / 7.9 / 96.2 / 0.52
2.0 / 24 / Non-Mayo Clinic: CI-NonA, with subjective report of cognitive decline / 5.6 / 97.8 / 0.52
1.0 / 143 / Non-Mayo Clinic: CI-NonA, without the requirement of subjective report of cognitive decline / 19.1 / 85.2 / 0.52
1.5 / 86 / Non-Mayo Clinic: CI-NonA, without the requirement of subjective report of cognitive decline / 9.0 / 90.7 / 0.50
2.0 / 47 / Non-Mayo Clinic: CI-NonA, without the requirement of subjective report of cognitive decline / 6.7 / 95.0 / 0.51
1.0 / 139 / Combination of each of the three fulldefinitions mapped in this publication (A-MCI, CI-Multi, CI-NonA) / 36.0 / 87.5 / 0.62
1.5 / 79 / Combination of each of the three full definitions mapped in this publication (A-MCI, CI-Multi, CI-NonA) / 24.7 / 93.2 / 0.59
2.0 / 46 / Combination of each of the three full definitions mapped in this publication (A-MCI, CI-Multi, CI-NonA) / 16.9 / 96.2 / 0.57
1.0 / 302 / Combination of each of the three definitions (without the requirement of subjective complaint) mapped in this publication (A-MCI, CI-Multi, CI-NonA) / 57.3 / 70.8 / 0.64
1.5 / 156 / Combination of each of the three definitions (without the requirement of subjective complaint) mapped in this publication (A-MCI, CI-Multi, CI-NonA) / 32.6 / 85.2 / 0.59
2.0 / 86 / Combination of each of the three definitions (without the requirement of subjective complaint) mapped in this publication (A-MCI, CI-Multi, CI-NonA) / 23.6 / 92.1 / 0.58
Leipzig Longitudinal Study of the Aged (LEILA75+), Germany5 / 3(mean2.6) / 75 / Dementia / DSM-IV / 89 / DSM-IV (60 AD, 15 VaD, 14 other) / Cut-off≤26 / 335 / Mini Mental State Examination cut-off score / 77.5 / 70.1 / 0.74
Leipzig Longitudinal Study of the Aged (LEILA75+), Germany6 / 4.3 / 75 / Dementia / DSM-IV / 171 / DSM-IV (89 AD, 42 VaD, 40 other) / 1.0 / 164 / Mayo Clinic: C-MCI / 50.3 / 84.8 / 0.68
1.5 / 80 / Mayo Clinic: C-MCI / 28.7 / 91.0 / 0.60
1.0 / 346 / Mayo Clinic: C-MCI, without the requirement of SMC / 74.3 / 73.3 / 0.74
1.5 / 144 / Mayo Clinic: C-MCI, without the requirement of SMC / 40.4 / 96.1 / 0.63
Eugeria Longitudinal Study of Cognitive Aging, France7 / ≤3 / 60 / Dementia / DSM-III-R / 19 / - / 1.0 / 27 / Mayo Clinic: A-MCI / 5.3 / 91.8 / 0.49
1.0 / 174 / AACD / 94.7 / 54.1 / 0.74
Abbreviations: AACD, aging-associated cognitive decline;A-MCI,anmestic MCI; AD,Alzheimer disease; AUC, area under the receiver operating characteristic curve; CI-Multi,cognitive impairment multi domain (impairment in at least two domains and subjective or informant report of cognitive decline); CI-NonA, CI single nonamnestic domain (impairment in a single nonmemory domain and subjective report of cognitive decline); C-MCI,combined MCI (combination of A-MCI, M-MCI, N-MCI [nonamnestic single domain MCI], multi domain N-MCI [memory preserved but impairment in two or more non-memory domains]); DSM, Diagnostic and Statistical Manual of Mental Disorders; MCI, mild cognitive impairment; MCIr, revised MCI;M-MCI, multipledomain A-MCI; NINCDS–ADRDA, Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders;Pro-AD,probable AD; R-MCI, revised MCI; SMC, subjective memory complaint; VaD, vascular disease.
1.Artero, S., Petersen, R., Touchon, J. & Ritchie, K. Revised criteria for mild cognitive impairment: validation within a longitudinal population study. Dement. Geriatr. Cogn. Disord.22, 465–470 (2006).
2.Baars, M. A. et al. Predictive value of mild cognitive impairment for dementia. The influence of case definition and age. Dement.Geriatr. Cogn. Disord.27, 173–181 (2009).
3.Busse, A., Bischkopf, J., Riedel-Heller, S. G. & Angermeyer, M. C. Mild cognitive impairment: prevalence and incidence according to different diagnostic criteria: results of the Leipzig Longitudinal Study of the Aged (LEILA75+). Br. J. Psychiatry182, 449–454 (2003).
4.Busse, A., Bischkopf, J., Riedel-Heller, S. G. & Angermeyer, M. C. Subclassifications for mild cognitive impairment: prevalence and predictive validity. Psychol. Med.33, 1029–1038 (2003).
5.Busse, A., Bischkopf, J., Riedel-Heller, S. G. & Angermeyer, M. C. Mild cognitive impairment: prevalence and predictive validity according to current approaches. Acta Neurol. Scand.108, 71–81(2003).
6.Busse, A., Hensel, A., Gühne, U., Angermeyer, M. C. & Riedel-Heller, S. G. Mild cognitive impairment: long-term course of four clinical subtypes. Neurology67, 2176–2185 (2006).
7.Ritchie, K., Artero, S. & Touchon, J. Classification criteria for mild cognitive impairment: a population-based validation study. Neurology56, 37–42 (2001).