Neurobiology of suicide: do biomarkers exist?

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List of additional references

S1. United Nations (2009) World Population prospects: the 2008 revision, Vol. 1, Comprehensive tables and United Nations, Highlights. Popul Dev Rev 36:854-855

S2. WHO. World report on violence and health. Geneva: World Health organization, 2002

S3. O’Carroll PW, Berman AL, Maris RW, Moscicki EK, Tanney BL, Silverman MM (1996) Beyond the Tower of Babel: a nomenclature for suicidology. Suicide Life Threat Behav 26:237-252

S4. Malafosse A (2005) Genetics of suicidal behavior. Am J Med Genet C Semin Med Genet 133C:1-2

S5. Goldsmith SK, Pellmar TC, Kleinman AM, Bunney WE (Eds) (2002) Reducing suicide: a national imperative. Washington, DC: The National Academies Press

S6. Stanistreet D, Taylor S, Jeffrey V, Gabbay M (2001) Accident or suicide? Predictors of coroners’ decisions in suicide and accident verdicts. Med Sci Law 41:111-115

S7. Parai JL, Kreiger N, Tomlinson G, Adlaf EM (2006) The validity of the certification of manner of death by Ontario coroners. Ann Epidemiol 16:805-811

S8. Lu TH, Sun SM, huang SM, Lin JJ (2006) Mind your manners: quality of manner of death certification among medical examiners and coroners in Taiwan. Am J Forensic Med Pathol 27:352-354

S9. Värnik P, Sisask M, Värnik A, Laido Z, Meise U, Ibelshäuser A, Van Audenhove C, Reynders A, Kocalevent RD, Kopp M, Dosa A, Arensman E, Coffey C, van der Feltz-Cornelis CM, Gusmão R, Hegerl U (2010) Suicide registration in eight European countries: a quantitative analysis of procedures and practices. Forensic Sci Int 10:86-92

S10. Qin P, Agerbo E, Mortensen PB (2002) Suicide risk in relation to family history of completed suicide and psychiatric disorders: a nested case-control study based on longitudinal registers. Lancet 360:1126-1130

S11. McGirr A, Alda M, Séguin M, Cabot S, Lesage A, Turecki G (2009) Familial aggregation of suicide explained by cluster B traits: a three-group family study of suicide controlling for major depressive disorder. Am J Psychiatry 166:1124-1134

S12. Angst J, Degonda M, Ernst C (1992) The Zurich Study: XV. Suicide attempts in a cohort from age 20 to 30. Eur Arch Psychiatry Clin Neurosci 242:135-141

S13. Dube SR, Anda RF, Felitti VJ, Chapman DP, Williamson DF, Giles WH (2001) Childhood abuse, household dysfunction, and the risk of attempted suicide throughout the life span: findings from the adverse childhood experiences study. JAMA 286:3089-3096

S14. Fergusson DM, Boden JM, Horwood LJ (2008) Exposure to childhood sexual and physical abuse and adjustment in early adulthood. Child Abuse Negl 32:607-619

S15. Mann JJ, Apter A, Bertolote J, Beautrais A, Currier D, Haas A, Hegerl U, Lonnqvist J, Malone K, Marusic A, Mehlum L, Patton G, Phillips M, Rutz W, Rihmer Z, Schmidtke A, Shaffer D, Silverman M, Takahashi Y, Varnik A, Wasserman D, Yip P, Hendin H (2005) Suicide prevention strategies. JAMA 294:2064-2074

S16. Agerbo E, Gunnell D, Bonde JP, Mortensen PB, Nordentoft M (2007) Suicide and occupation: the impact of socio-economic, demographic and psychiatric differences. Psycho Med 37:1131-1140

S17. Li Z, Page A, Martin G, Taylor R (2011) Attributable risk of psychiatric and socio-economic factors for suicide from individual-level, population-based studies: a systematic review. Soc Sci Med 72:608-616

S18. Schneider B, Grebner K, Schnabel A, Hampel H, Georgi K, Seidler A (2011) Impact of employment status and work-related factors on risk of completed suicide. A case-control psychological autopsy study. Psychiatry Res 190:265-270

S19. Maris RW, Berman AL, Silverman MM (2000) Comprehensive Textbook of Suicidology. New York, Guilford Pr: 26-61

S20. Mann JJ, Waternaux C, Haas GL, Malone KM (1999) Toward a clinical model of suicidal behavior in psychiatric patients. Am J Psychiatry 156:181-189

S21. Mann JJ (2002) A current perspective of suicide and attempted suicide. Ann Intern Med 136:302-311

S22. Brent DA, Mann JJ (2005) Family genetic studies, suicide, and suicidal behavior. Am J Med Genet C Semin Med Genet 133C:13-24

S23. Sibille E, Arango V, Galfalvy HC, Pavlidis P, Erraji-Benchekroun L, Ellis SP, Mann JJ (2004) Gene expression profiling of depression and suicide in human prefrontal cortex. Neuropsychopharmachology 29:351-361

S24. Gwadry F, Sequeira A, Hoke G, ffrench-Mullen JMH, Turecki G (2005) Molecular characterization of suicide by microarray analysis. American Journal of Medical Genetics Part C (Semin Med Genet) 133C:48-56

S25. Sequeira A, Klempan T, Canetti L, ffrench-Mullen J, Benkelfalt C, Rouleau GA, Turecki G (2007) Patterns of gene expression in the limbic system of suicides with and without major depression. Mol Psychiatry 12:640-655

S26. Sequeira A, Mamdani F, Ernst C, Vaeter MP, Bunney WE, Lebel V, Rehal S, Klempan T, Gratton A, Benkelfat C, Rouleau GA, Naguib M, Turecki G (2009) Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression. PLoS ONE;4:e6585

S27. Klempan TA, Rujescu D, Mérette C, Himmelman C, Sequeira A, Canetti L, Fiori LM, Schneider B, Bureau A, Turecki G (2009) Profiling brain expression of the spermidine/spermine N1-acetyltransferase 1 (SAT1) gene in suicide. Am J Med Genet part B 150B:934-94

S28. Galfalvy H, Zalsman G, Huang Y-Y, Murphy L, Rosoklija G, Dwork AJ, Haghighi F, Arango V, Mann JJ (2011) A pilot genome wide association and gene expression array study of suicide with and without major depression. World J Biol Psychiatry. doi:10.3109/15622975.2011.597875

S29. Smalheiser NR, Lugli G, Rizavi HS, Torvik VI, Turecki G, Dwivedi Y (2012) MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects. PLoS ONE 3, e33201. doi:10.1371/journal.pone.0033201

S30. Griffiths AJF, Wessler SR, Carroll SB, Doebley J (2012) Introduction to Genetic Analysis. W.H. Freeman and Company, New York, tenth edition

S31. Stanley M, Mann JJ (1983) Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet 1:214-216

S32. Arango V, Underwood MD, Gubbi AV, Mann JJ (1995) Localized alterations in pre- and post- synaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Res 688:121-133

S33. Mann JJ, HuangYY, Underwood MD, Kassir SA, Oppenheim S, Kelly TM, Dwork AJ, Arango V (2000) A serotonin transporter gene promoter polymorphysm (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry 57:729-738

S34. Asberg M, Traskman L, Thoren P (1979) 5-HIAA in the cerebrospinal fluid: a biochemical suicide predictor? Arch Gen Psychiatry 33:1193-119

S35. Malone KM, Corbitt EM, Li S, Mann JJ (1996) Prolactin response to fenfluramine and suicide attempt lethality in major depression. Br J Psychiatry 168:324-329

S36. Turecki G, Zhn Z, Tzenva J, Lesage A, Séguin M, Tousignant M, Chawky N, Vanier C, Lipp O, Alda M, Joober R, Benkelfat C, Rouleau GA (2001) TPH and suicidal behavior: a study in suicide completers. Mol Psychiatry 6:98-102

S37. Arango V, Yung-yu H, Underwood M D, Mann JJ (2003) Genetics of the serotoninergic system in suicidal behavior. Journal of Psychiatric Research 37:375-386

S38. Zill P, Büttner A, Eisenmenger W, Bondy B, Ackenheil M (2004) Regional mRNA expression of a second tryptophan hydroxilase isoform in postmortem tissue samples of two human brains. Eur Neuropsychopharmacol 14:282-284

S39. Ono H, Shirakawa O, Kitamura N, HashimotoT, Nishiguchi N, Nishimura A, Nushida H, Ueno Y, Maeda K (2002) Tryptophan hydroxylase immunoreactivity is altered by genetic variation in post-mortem brain samples of both suicide victims and controls. Mol Psychiatry 7:1127-1132

S40. Boldrini M, Underwood MD, Mann JJ, Arango V (2005) More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides. Brain Res 1041:19-28

S41. Bach-Mizrachi H, Underwood MD, Tin A, Ellis SP, Mann JJ, Arango V (2008) Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides. Mol Psychiatry 13:507-513

S42. Zill P, Büttner A, Eisenmenger W, Möller HJ, Bondy B, Ackenheil M (2004) Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims.Biol Psychiatry 56:581-6

S43. Bach-Mizrachi H, Underwood MD, Kassir SA, Bakalian MJ, Sibille E, Tamir H, Mann JJ, Arango V (2006) Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. Neuropsychopharmacology 31:814-24

S44. De Luca V, Likhodi O, Van Tol HH, Kennedy JL, Wong AH (2006) Gene expression of tryptophan hydroxylase 2 in post-mortem brain of suicide subjects. Int J Neuropsychopharmacol 9:21-5

S45. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Müller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-31

S46. Preuss UW, Soyka M, Bahlmann M, Wenzel K, Behrens S, de Jonge S, Krüger M, Bondy B (2000) Serotonin transporter gene regulatory region polymorphism (5-HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity.Psychiatry Res96:51-61

S47. Courtet P, Baud P, Abbar M, Boulenger JP, Castelnau D, Mouthon D, Malafosse A, Buresi C (2001) Association between violent suicidal behavior and the low activity allele of the serotonin transporter gene.Mol Psychiatry 6:338-341

S48. Bellivier F, Szöke A, Henry C, Lacoste J, Bottos C, Nosten-Bertrand M, Hardy P, Rouillon F, Launay JM, Laplanche JL, Leboyer M (2000) Possibleassociation between serotonin transportergene polymorphism and violent suicidal behavior in mood disorders.Biol Psychiatry 48:319-322

S49. Courtet P, Buresi C, Abbar M, Baud P, Boulenger JP, Castelnau D, Mouthon D, Malafosse A (2003) No association between non-violent suicidal behavior and the serotonin transporter promoter polymorphism.Am J Med Genet B Neuropsychiatr Genet 116B:72-76

S50. Anguelova M, Benkelfat C, Turecki G (2003) A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I Affective disorders. Mol Psychiatry 8:574-591

S51. Li D, He L (2007) Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior.Mol Psychiatry 12:47-54

S52. Turecki G, Brière R, Dewar K, Antonetti T, Lesage AD, Séguin M, Chawky N, Vanier C, Alda M, Joober R, Benkelfat C, Rouleau GA (1999) Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. Am J Psychiatry 156:1456-1458

S53. Oquendo MA, Russo SA, Underwood MD, Kassir SA, Ellis SP, Mann JJ, Arango V (2006) Higher postmortem prefrontal 5-HT2A receptor binding correlates with lifetime aggression in suicide. Biol Psychiatry 59:235-243

S54. Alda M, Hrdina PD (2000) Distribution of platelet 5-HT(2A) receptor densities in suicidal and non-suicidal depressives and control subjects. Psychiatry Res 94:273-277

S55. Arias B, Gastó C, Catalán R, Gutiérrez B, Pintor L, Fañanás L (2001) The 5-HT(2A) receptor gene 102T/C polymorphism is associated with suicidal behavior in depressed patients. Am J Med Genet 105:801-804

S56. Ono H, Shirakawa O, Nishiguchi N, Nishimura A, Nushida H, Ueno Y, Maeda K (2001) Serotonin 2A receptor gene polymorphism is not associated with completed suicide. Psychiatr Res 35:173-176

S57. Khait VD, Huang YY, Zalsman G, Oquendo MA, Brent DA, Harkavy-Friedman JM, Mann JJ (2005) Association of serotonin 5-HT2A receptor binding and the T102C polymorphism in depressed and healthy Caucasian subjects. Neuropsychopharmacology 30:166-172

S58. Pandey GN (2011) Neurobiology of adult and teenage suicide. Asian J Psychiatr 4:2-13

S59. Bondy B, Kuznik J, Baghai T, Schüle C, Zwanzger P, Minov C, de Jonge S, Rupprecht R, Meyer H, Engel RR, Eisenmenger W, Ackenheil M (2000) Lack of association of serotonin-2A receptor gene polymorphism (T102C) with suicidal ideation and suicide. Am J Med Genet 96:831-835

S60. Rujescu D, Giegling I, Sato T, Möller HJ (2003) Lack of association between serotonin 5-HT1B receptor gene polymorphism and suicidal behavior.Am J Med Genet B Neuropsychiatr Genet 116B:69-71

S61. Turecki G, Sequeira A, Gingras Y, Séguin M, Lesage A, Tousignant M, Chawky N, Vanier C, Lipp O, Benkelfat C, Rouleau GA (2003) Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers. Am J Med Genet B Neuropsychiatric Genet 118B:36-40

S62. Choudary PV Molnar M, Evans SJ, Tomita H, Li JZ, Vawter MP, Myers RM, Bunney WE Jr, Akil H, Watson SJ, Jones EG (2005) Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci USA 102:15653-15658

S63. Kim S, Choi KH, Baykiz AF, Gershenfeld HK (2007) Suicide candidate genes associated with bipolar disorder and schizophrenia: an explanatory gene expression profiling analysis of post-mortem prefrontal cortex. BMC Genom 8:413-416

S64. Noga JT, Hyde TM, Herman MM, Spurney CF, Bigelow LB, Weinberger DR, Kleinman JE (1997) Glutamate receptors in the postmortem striatum of schizophrenic, suicide and control brains. Synapse 27:168-176

S65. Valdizán EM, Díez-Alarcia R, González-Maeso J, Pilar-Cuéllar F, García-Sevilla JA, Meana JJ, Pazos A (2010) α2-adrenoceptor functionality in postmortem frontal cortex of depressed suicide victims. Biol Psychiatry 68:869-872

S66. Allard P, Norlen M (2001). Caudate nucleus dopamine D(2) receptors in depressed suicide victims. Neuropsychobiology 44:70-73

S67. Gonzalez-Maeso J, Rodriguez-Puertas R, Meana JJ, Garcia-Sevilla JA, Guimon J (2002) Neurotransmitter receptors-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)adrenoreceptors. Mol Psychiatry 7:755-767

S68. Gross-Isseroff R, Dillon KA, Israeli M, Biegon A (1990) Regionally selective increases in mu opioid receptor density in the brains of suicide victims. Brain Res 530: 312-316

S69. Gabilondo AM, Meana JJ, Garcia-Sevilla JA (1995) Increased density of mu-opioid receptors in the postmortem brain of suicide victims. Brain Res 682:245-250

S70. Currier D, Mann JJ (2008) Stress, genes and the biology of suicidal behavior. Psychiatr Clin North Am 31:247-269

S71. Jokinen J, Nordström AL, Nordström P (2008) ROC analysis of dexamethasone suppression test threshold in suicide prediction after attempted suicide. J Affect Disord 106:145-152

S72. Jokinen J, Nordström AL, Nordström P (2009) CSF 5-HIAA and DST non-suppression – Orthogonal biologic risk factors for suicide in male mood disorder inpatients. Psychiatry Res 165:96-110

S73. Raadsheer FC, Hoogendijk WJ, Stam FC, Tilders FJ, Swaab DF (1994) Increased numbers of corticotrophin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients. Neuroendocrinology 60:436-444

S74. Wang SS, Kamphuis W, Huitinga I, Zhou JN, Swaab DF (2008) Gene expression analysis in the human hypothalamus in depression by laser microdissection and real-time PCR: the presence of multiple receptor imbalances. Mol Psychiatry 13:786-799

S75. Lopez JF, Palkovits M, Arató M, Mansour A, Akil H, Watson SJ (1992) Localization and quantification of pro-opiomelanocortin mRNA and glucocorticoid receptor mRNA in pituitaries of suicide victims. Neuroendocrinology 56:491-501

S76. Nemeroff CB, Owens MJ, Bissette G, Andorn AC, Stanley M(1988) Reduced corticotrophin releasing factor binding sites in the frontal cortex of suicide victims. Arch Gen Psychiatry 45:577-579

S77. Hiroi N, Wong ML, Licinio J, Park C, Young M, Gold PW, Chrousos GP, Bornstein SR(2001) Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls. Mol Psychiatry 6:540-546

S78. Austin MC, Janosky JE, Murphy HA(2003) Increased corticotropin-releasing hormone immunoreactivity in monoamine-containing pontine nuclei of depressed suicide men. Mol Psychiatry 8:324-332

S79. Merali Z, Kent P, Du L, Hrdina P, Palkovits M, Faludi G, Poulter MO, Bédard T, Anisman H(2006) Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and control subjects. Biol Psychiatry 59:594-602

S80. Merali Z, Du L, Hrdina P, Palkovits M, Faludi G, Poulter MO, Anisman H (2004) Dysregulation in the suicide brain: mRNA expression of corticotropin-releasing hormone receptors and GABA (A) receptor subunits in frontal cortical brain region. J Neurosci 24:1478-1485

S81. Alt SR, Turner JD, Klok MD, Meijer OC, Lakke EA, DeRijk RH, Muller CP (2010) Differential expression of glucorticoid receptor transcripts in major depressive disorder is not epigenetically programmed. Psychoneuroendocrinology 35:544-556

S82. Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Taminga CA, Pandey GN (2003) Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in post-mortem brain of suicide subjects. Arch Gen Psychiatry 60:804-815

S83. Dwivedi Y, Mondal AC, Rizavi HS, Conley RR (2005) Suicide brain is associated with decreased expression of neurotrophins. Biol Psychiatry 58:315-324

S84. Pandey GN, Ren X, Rizavi HS, Conley RR, Roberts RC, Dwivedi Y (2008) Brain-derived neurotrophic factor and tyrosine kinase B receptor signaling in postmortem brain of teenage suicide victims. Int J Neuropsychopharmacol 11:1047-1061

S85. Karege F, Vaudan G, Schwald M, Perroud N, La Harpe R (2005) Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs. Mol Brain Res 136:29-37

S86. Roth TL, Zoladz PR, Sweatt JD, Diamond DM (2011) Epigenetic modification of hippocampal BDNF DNA in adult rats in an animal model of post-traumatic stress disorder. J Psychiatr Res 45:919-926

S87. Ernst C, Chen ES, Turecki G(2009) Histone methylation and decreased expression of TrkB.T1 in orbital frontal cortex of suicide completers. Mol Psychiatry 14:830-832

S88. Ernst C, Deleva V, Deng X, Sequeira A, Pomarenski A, Klempan T, Ernst N, Quirion R, Gratton A, Szyf M, Turecki G(2009) Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Arch Gen Psychiatry 66:22-32

S89. Keller S, Sarchiapone M, Zarrilli F, Tomaiuolo R, Carli V, Angrisano T, Videtic A, Amato F, Pero R, di Giannantonio M, Iosue M, Lembo F, Castaldo G, Chiariotti L (2011) TrkB gene expression and DNA methylation state in Wernicke area does not associate with suicidal behavior. J Affect Disord 135:400-404

S90. Coull MA, Lowter S, Katona CL, Horton RW (2000) Altered brain protein kinase C in depression: a post-mortem study. Eur Neuropsychopharmachol 10:283-288

S91. Pandey GN, Dwivedi Y, Rizavi HS, Ren X, Conley RR (2004) Decreased catalytic activity and expression of protein kinase C isozyme in teenage suicide victims: a post-mortem brain study. Arch Gen Psychiatry 61:685-693

S92. Choi K, Le T, Xing G, Johnson LR, Ursano RJ (2011) Analysis of kinase gene expression in the frontal cortex of suicide victims: implications of fear and stress. Front Behav Neurosci 5:46

S93. Dwivedi Y, Rizavi HS, Shukla PK, Lyons J, Faludi G, Palkovits M, Sarosi A, Conley RR, Roberts RC, Tamminga CA, Pandey GN(2004) Protein kinase A in postmortem brain of depressed suicide victims: altered expression of specific regulatory and catalytic subunits. Biol Psychiatry 55:234-243

S94. Pandey GN, Dwivedi Y, Ren X, Rizavi HS, Mondal AC, Shukla PK, Conley RR (2005) Brain region specific alterations in the protein and mRNA levels of protein kinase A subunits in the post-mortem brain of teenage suicide victims. Neuropsychopharmacology 30:1548-1556

S95.Yamada S, Yamamoto M, Ozawa H, Riederer P, Saito T (2003) Reduced phosphorylation of cyclic AMP-responsive element binding protein in the post-mortem orbitofrontal cortex of patients with major depressive disorder. J Neural Transm 110:671-680

S96. Dwivedi Y, Rao JS, Rizavi HS, Kotowski J, Conley RR, Roberts RC, Tamminga CA, Pandey GN(2003) Abnormal expression and functional characteristics of cyclic adenosine monophosphate response element binding protein in post-mortem brain of suicide subjects. Arch Gen Psychiatry 60:273-282

S97. Perlis RH, Purcell S, Fagerness J, Cusin C, Yamaki L, Fava M, Smoller JW (2007) Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder. Biol Psychiatry 62:536-540

S98. Pandey GN, Dwivedi Y, Ren X, Rizavi HS, Roberts RC, Conley RR(2007) Cyclic AMP response element-binding protein in post-mortem brain of teenage suicide victims: specific decrease in the prefrontal cortex but not the hippocampus. Int J Neuropsychopharmacol 10:621-629

S99. Karege F, Perroud N, Burkhardt S, Schwald M, Ballmann E, La Harpe R, Malafosse A (2007) Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase-3β in ventral prefrontal cortex of depressed suicide victims. Biol Psychiatry 61:240-245

S100. Svenningsson P, Chergui K, Rachleff I, Flajolet M, Zhang X, El Yacoubi M, Vaugeois JM, Nomikos GG, Greengard P (2006) Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 311:77-80

S101. Zhang L, Li H, Su TP, Barker JL, Maric D, Fullerton CS, Webster MJ, Hough CJ, Li XX, Traumatic Stress Brain Study Group, Ursano R (2008) p11 is up-regulated in the forebrain of stressed rats by glucocorticoid acting via two specific glucocorticoid response elements in the p11 promoter. Neuroscience 153:1126-1134

S102. Su TP, Zhang L, Chung MY, Chen YS, Bi YM, Chou YH, Barker JL, Barrett JE, Maric D, Li XX, Li H, Webster MJ, Benedek D, Carlton JR, Ursano R (2009) Levels of the potential biomarker p11 in peripheral blood cells distinguish patients with PTSD from those with other major psychiatric disorders. J Psychiatr Res 43:1078-1085

S103. Fiori LM, Turecki G (2008) Implication of the polyamine system in mental disorders. J Psychiatry Neurosci 33:102-110

S104. Sequeira A, Gwadry FG, ffrench-Mullen J, Canetti L, Gingras Y, Casero Jr RA, Rouleau G, Benkelfat C, Turecki G (2006) Implication of SSAT by gene expression and genetic variation in suicide and major depression. Arch Gen Psychiatry 63:35-48

S105. Guipponi M, Deutsch S, Kohler K, Perroud N, Le Gal François, Vessaz M, Laforge T, Petit B, Jollant F, Guillaume S, Baud P, Courtet P, La Harpe R, Malafosse A (2009) Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior. Am J Med Genet Part B 150B:799-807

S106. Fiori LM, Mechawar N, Turecki G (2009) Identification and characterization of SAT1 promoter variants in suicide completers. Biol Psychiatry 66:460-467

S107. Fiori LM, Turecki G (2010) Association of the SAT1 In/del polymorphism with suicide completion. Am J Med Genet B Neuropsychiatr Genet 153B:825-829

S108. Fiori LM, Gross JA, Turecki G(2011) Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide. Int J Neuropsychopharmacol 19:1-6

S109. Fiori LM, Turecki G (2011) Epigenetic regulation of spermidine/spermine N1-acetyltransferase (SAT1) in suicide. J Psychiatr Res 45:1229-1235

S110. Rajkowska G (2000) Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells. Biol Psychiatry 48:766-777

S111. Knable MB, Barci BM, Webster MJ, Meador-Wooddruff J, Torrey EF, Stanley Neuropathology Consortium (2004) Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. Mol Psychiatry 9:609-620

S112. Miguel-Hidalgo JJ, Baucom C, Diley G, Overholser JC, Meltzer HY, Stockmeier CA, Rajkowska G (2000) Glial fibrillary acid protein immunoreactivity in the prefrontal cortex distinguishes younger from older adults in major depressive disorder. Biol Psychiatry 48:861-873

S112. Davis S, Thomas A, Perry R. Oakley A, Kalaria RN, O’Brien JT (2002) Glial fibrillary acid protein in late life major depressive disorder: an immunocytochemical study. J Neurol Neurosurg Psychiatry 73:556-560